PURPOSE: The limitations and morbidity associated with autogenous bone grafting have driven the search for predictable bone substitutes and bioimplants. A novel method of reconstruction was tested in this case series. MATERIALS AND METHODS: Ten patients with major mandibular defects following resection of biopsy-proven ameloblastoma lesions or osteomyelitis of the mandibular body or ramus were included in this study. The resection defects were spanned with rigid reconstruction plates to hold the remaining mandibular segments in the correct position. The defects were filled with a bioimplant containing bone morphogenetic protein-7 (BMP-7) in a demineralized bone matrix (DBM) suspended in a reverse-phase medium to effect sustained BMP delivery. RESULTS: The postoperative course for all 10 patients was uneventful. Radiographic evidence of mandibular bone formation was found in all cases. At the end of 1 year, functional and esthetic reconstruction of the mandible was complete. CONCLUSION: Bioimplants containing BMP-7 in DBM suspended in a reverse phase medium were successful in restoring major mandibular defects in nonirradiated beds in this series of 10 patients.
PURPOSE: The limitations and morbidity associated with autogenous bone grafting have driven the search for predictable bone substitutes and bioimplants. A novel method of reconstruction was tested in this case series. MATERIALS AND METHODS: Ten patients with major mandibular defects following resection of biopsy-proven ameloblastoma lesions or osteomyelitis of the mandibular body or ramus were included in this study. The resection defects were spanned with rigid reconstruction plates to hold the remaining mandibular segments in the correct position. The defects were filled with a bioimplant containing bone morphogenetic protein-7 (BMP-7) in a demineralized bone matrix (DBM) suspended in a reverse-phase medium to effect sustained BMP delivery. RESULTS: The postoperative course for all 10 patients was uneventful. Radiographic evidence of mandibular bone formation was found in all cases. At the end of 1 year, functional and esthetic reconstruction of the mandible was complete. CONCLUSION: Bioimplants containing BMP-7 in DBM suspended in a reverse phase medium were successful in restoring major mandibular defects in nonirradiated beds in this series of 10 patients.
Authors: Olli-Pekka Lappalainen; Riikka Korpi; Marianne Haapea; Jarkko Korpi; Leena P Ylikontiola; Soili Kallio-Pulkkinen; Willy S Serlo; Petri Lehenkari; George K Sándor Journal: Childs Nerv Syst Date: 2014-11-13 Impact factor: 1.475
Authors: Landon S Pryor; Earl Gage; Claude-Jean Langevin; Fernando Herrera; Andrew D Breithaupt; Chad R Gordon; Ahmed M Afifi; James E Zins; Hal Meltzer; Amanda Gosman; Steve R Cohen; Ralph Holmes Journal: Craniomaxillofac Trauma Reconstr Date: 2009-10
Authors: Nattharee Chanchareonsook; Rüdiger Junker; Leenaporn Jongpaiboonkit; John A Jansen Journal: Tissue Eng Part B Rev Date: 2013-08-28 Impact factor: 6.389
Authors: Adam S DeConde; Douglas Sidell; Min Lee; Olga Bezouglaia; Kyle Low; David Elashoff; Tristan Grogan; Sotirios Tetradis; Tara Aghaloo; Maie St John Journal: Laryngoscope Date: 2013-04-02 Impact factor: 3.325