BACKGROUND: This study evaluated the inflammatory reaction at the site of overlapping drug-eluting stents (DES) in a porcine model of in-stent restenosis. METHODS AND RESULTS: Twenty bare metal stents (BMS) (group I; n=10), 20 sirolimus-eluting stents (SES) (group II: n=10), 20 paclitaxel-eluting stent (PES) (group III: n=10), and 10 PES and 10 SES (group IV: n=10) were overlapped in the left anterior descending coronary arteries of 40 pigs. Follow-up coronary angiography and histopathology were performed at 4 weeks after stenting. For the overlapped segments, the minimal luminal diameter at 4 weeks was smaller in group I than in the other groups (1.78+/-0.13 mm, 2.79+/-0.09 mm, 2.90+/-0.04 mm, 2.80+/-0.07 mm, respectively; p<0.001), and the neointimal area (5.51+/-0.58 mm2, 2.38+/-0.53 mm2, 2.07+/-0.37 mm2, 2.39+/-0.58 mm2, respectively; p<0.001) and area stenosis (68.74+/-4.02%, 27.79+/-4.73%, 23.66+/-3.24%, 27.63+/-4.07%, respectively; p<0.001) were higher in group I than in the other groups; however, the inflammatory score was higher in group III than in the other groups (1.80+/-0.42, 2.10+/-0.32, 2.90+/-0.31, 2.50+/-0.52, respectively; p<0.001) and the endothelization score was lower in group III than in the other groups (2.80+/-0.42, 2.30+/-0.67, 1.30+/-0.48, 2.10+/-0.74, respectively; p<0.001). CONCLUSION: Compared with BMS, DES inhibit neointimal hyperplasia, but inflammation and poor endothelization occur at the site of overlapping stents.
BACKGROUND: This study evaluated the inflammatory reaction at the site of overlapping drug-eluting stents (DES) in a porcine model of in-stent restenosis. METHODS AND RESULTS: Twenty bare metal stents (BMS) (group I; n=10), 20 sirolimus-eluting stents (SES) (group II: n=10), 20 paclitaxel-eluting stent (PES) (group III: n=10), and 10 PES and 10 SES (group IV: n=10) were overlapped in the left anterior descending coronary arteries of 40 pigs. Follow-up coronary angiography and histopathology were performed at 4 weeks after stenting. For the overlapped segments, the minimal luminal diameter at 4 weeks was smaller in group I than in the other groups (1.78+/-0.13 mm, 2.79+/-0.09 mm, 2.90+/-0.04 mm, 2.80+/-0.07 mm, respectively; p<0.001), and the neointimal area (5.51+/-0.58 mm2, 2.38+/-0.53 mm2, 2.07+/-0.37 mm2, 2.39+/-0.58 mm2, respectively; p<0.001) and area stenosis (68.74+/-4.02%, 27.79+/-4.73%, 23.66+/-3.24%, 27.63+/-4.07%, respectively; p<0.001) were higher in group I than in the other groups; however, the inflammatory score was higher in group III than in the other groups (1.80+/-0.42, 2.10+/-0.32, 2.90+/-0.31, 2.50+/-0.52, respectively; p<0.001) and the endothelization score was lower in group III than in the other groups (2.80+/-0.42, 2.30+/-0.67, 1.30+/-0.48, 2.10+/-0.74, respectively; p<0.001). CONCLUSION: Compared with BMS, DES inhibit neointimal hyperplasia, but inflammation and poor endothelization occur at the site of overlapping stents.
Authors: Jung Sun Cho; Myung Ho Jeong; Doo Sun Sim; Young Joon Hong; Kyung Seob Lim; Jung Ha Kim; Hyoung Doo Kim; Ju Yeal Baek; Hee Jeoung Yoon; Sung-Ho Her; Seung Won Jin; Ju Han Kim; Youngkeun Ahn; Jeong Gwan Cho; Jong Chun Park; Jung Chaee Kang Journal: J Korean Med Sci Date: 2010-04-16 Impact factor: 2.153
Authors: Khurshid Ahmed; Myung Ho Jeong; Rabin Chakraborty; Young Joon Hong; Doo Sun Sim; Sumera Ahmed; Seung Hwan Hwang; Min Goo Lee; Keun Ho Park; Ju Han Kim; Youngkeun Ahn; Myeong Chan Cho; Chong Jin Kim; Young Jo Kim; Jong Chun Park; Jung Chaee Kang Journal: J Korean Med Sci Date: 2012-10-30 Impact factor: 2.153
Authors: Seung-Woon Rha; Kang-Yin Chen; Dong Joo Oh; Yong-Jian Li; Zhe Jin; Kanhaiya Lal Poddar; Sureshkumar Ramasamy; Yoshiyasu Minami; Amro Elnagar; Byoung Geol Choi; Sang Pyo Hong; Byoung Won Cheon; Sang Ki Moon; Sung Il Im; Sun Won Kim; Jin Oh Na; Cheol Ung Choi; Hong Euy Lim; Jin Won Kim; Eung Ju Kim; Seong Woo Han; Chang Gyu Park; Hong Seog Seo; Jung Ha Kim; Young Joon Hong; Myung Ho Jeong Journal: Korean Circ J Date: 2012-06-28 Impact factor: 3.243
Authors: Kyung Seob Lim; Myung Ho Jeong; In Ho Bae; Jun-Kyu Park; Dae Sung Park; Jong Min Kim; Jung Ha Kim; Dong Lyun Cho; Doo Sun Sim; Keun-Ho Park; Young Joon Hong; Youngkeun Ahn Journal: Chonnam Med J Date: 2013-12-23