Literature DB >> 18294763

Aurora kinases as an anti-cancer target.

Takayuki Ikezoe.   

Abstract

The Aurora family of serine/threonine kinases plays an important role in chromosome alignment, segregation and cytokinesis during mitosis. Recent studies have found aberrant expression of Aurora kinases in a variety of human solid tumors and hematological malignancies, suggesting they have a role in carcinogenesis. This review highlights the function of Aurora kinases in the regulation of mitosis and presents the rationale for these kinases as an anti-cancer target. I also review recently developed inhibitors of Aurora kinases.

Entities:  

Mesh：

Substances：

Year:  2008        PMID： 18294763     DOI： 10.1016/j.canlet.2008.01.005

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  9 in total

1.  Some insights into the binding mechanism of Aurora B kinase gained by molecular dynamics simulation.

Authors:  Rui Xiong; Xiao-Mei Cai; Jing Wei; Peng-Yu Ren
Journal:  J Mol Model       Date:  2012-05-30       Impact factor: 1.810

2.  Gossypin inhibits gastric cancer growth by direct targeting of AURKA and RSK2.

Authors:  Li Wang; Xiangyu Wang; Hanyong Chen; Xueyin Zu; Fayang Ma; Kangdong Liu; Ann M Bode; Zigang Dong; Dong Joon Kim
Journal:  Phytother Res       Date:  2018-12-10       Impact factor: 5.878

3.  Copy-number increase of AURKA in gastric cancers in a Chinese population: a correlation with tumor progression.

Authors:  Zhengyu Fang; Yi Xiong; Jiana Li; Li Liu; Manhui Li; Chao Zhang; Wei Zhang; Jun Wan
Journal:  Med Oncol       Date:  2010-06-29       Impact factor: 3.064

4.  Antimyeloma activity of a multitargeted kinase inhibitor, AT9283, via potent Aurora kinase and STAT3 inhibition either alone or in combination with lenalidomide.

Authors:  Loredana Santo; Teru Hideshima; Diana Cirstea; Madhavi Bandi; Erik A Nelson; Gullu Gorgun; Scott Rodig; Sonia Vallet; Samantha Pozzi; Kishan Patel; Christine Unitt; Matt Squires; Yiguo Hu; Dharminder Chauhan; Anuj Mahindra; Nikhil C Munshi; Kenneth C Anderson; Noopur Raje
Journal:  Clin Cancer Res       Date:  2011-03-23       Impact factor: 12.531

5.  p53 is critical for the Aurora B kinase inhibitor-mediated apoptosis in acute myelogenous leukemia cells.

Authors:  Takayuki Ikezoe; Jing Yang; Chie Nishioka; Akihito Yokoyama
Journal:  Int J Hematol       Date:  2009-12-16       Impact factor: 2.490

6.  Ewing sarcoma fusion protein EWSR1/FLI1 interacts with EWSR1 leading to mitotic defects in zebrafish embryos and human cell lines.

Authors:  Lisa J Embree; Mizuki Azuma; Dennis D Hickstein
Journal:  Cancer Res       Date:  2009-05-05       Impact factor: 12.701

7.  Expression of aurora kinase A and B in chondrosarcoma and its relationship with the prognosis.

Authors:  Xiaohui Liang; Danying Wang; Yan Wang; Zhiqiang Zhou; Juan Zhang; Jinsong Li
Journal:  Diagn Pathol       Date:  2012-07-18       Impact factor: 2.644

Review 8.  Therapeutic Targets and Emerging Treatments in Advanced Chondrosarcoma.

Authors:  Shinji Miwa; Norio Yamamoto; Katsuhiro Hayashi; Akihiko Takeuchi; Kentaro Igarashi; Hiroyuki Tsuchiya
Journal:  Int J Mol Sci       Date:  2022-01-20       Impact factor: 5.923

Review 9.  Immunotherapy for Chordoma and Chondrosarcoma: Current Evidence.

Authors:  Jeffrey I Traylor; Mark N Pernik; Aaron R Plitt; Michael Lim; Tomas Garzon-Muvdi
Journal:  Cancers (Basel)       Date:  2021-05-17       Impact factor: 6.639
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.