| Literature DB >> 18289774 |
Peng Gao1, Geng-Yin Zhou, Qing-Hui Zhang, Lei Xiang, Shun-Li Zhang, Chao Li, Yan-Lin Sun.
Abstract
Lymphangiogenesis has recently been considered important for spread of malignant tumors. In the present study, lymphatic vessel density (LVD) including peritumoral LVD (P-LVD) and intratumoral LVD (I-LVD) was determined, respectively, by immunohistochemical staining with the antibody to LYVE-1 in 63 cases of early gastric carcinoma and 105 cases of advanced gastric carcinoma. The aim of the study is to investigate whether or not increased LVD could be a risk factor for nodal metastasis and survival. We conclude that increased P-LVD, but not I-LVD, could serve as an independent risk factor for nodal metastasis, recurrence and overall survival in gastric carcinoma.Entities:
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Year: 2008 PMID： 18289774 DOI： 10.1016/j.canlet.2008.01.017
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679