Literature DB >> 18285467

Blockade of IP3-mediated SK channel signaling in the rat medial prefrontal cortex improves spatial working memory.

Avis R Brennan1, Beth Dolinsky, Mai-Anh T Vu, Marion Stanley, Mark F Yeckel, Amy F T Arnsten.   

Abstract

Planning and directing thought and behavior require the working memory (WM) functions of prefrontal cortex. WM is compromised by stress, which activates phosphatidylinositol (PI)-mediated IP3-PKC intracellular signaling. PKC overactivation impairs WM operations and in vitro studies indicate that IP3 receptor (IP3R)-evoked calcium release results in SK channel-dependent hyperpolarization of prefrontal neurons. However, the effects of IP3R signaling on prefrontal function have not been investigated. The present findings demonstrate that blockade of IP3R or SK channels in the prefrontal cortex enhances WM performance in rats, suggesting that both arms of the PI cascade influence prefrontal cognitive function.

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Year:  2008        PMID： 18285467      PMCID： PMC2275660          DOI： 10.1101/lm.767408

Source DB:  PubMed          Journal:  Learn Mem        ISSN： 1072-0502            Impact factor:   2.460


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