OBJECTIVES: To compare the health-related quality of life among adult males affected with mild hemophilia A due to the same mutation (Val2016ala) to that of unaffected age and sex matched controls from the same general population. METHODS: The Short-Form 36 (SF-36) and Health Assessment Questionnaire (HAQ) were used to measure health-related quality of life and physical function. Other measures included bleeding history, a measure of joint damage, body mass index, age, and viral infection status. Cross-sectional data were collected through research clinics and a retrospective chart audit over a two-year period. RESULTS AND CONCLUSIONS: The study included 47 affected males and 33 controls. The affected males had a higher level of co-morbidity, prior bleeding, and existing joint damage than controls. With the exception of the social function and health transition scales, mean scores for each of the SF-36 domains were worse among affected males. Mean differences were more than a clinically important five points in five of eight domains, with the general health scale showing more than a 10-point difference. Despite the degree of difference noted, only two of the differences were statistically significant (general health and role emotional scales) because of the small sample size and considerable individual variation in SF-36 scale scores. Multiple regression analyses suggested existing joint damage and presence of heart disease as the strongest associates of lower physical health-related quality of life. Joint damage in turn was partly related to prior hemarthroses. Compared to the Canadian population, affected males had lower scores in six out of eight SF-36 domains as well as the physical component summary score. There were no significant differences found in the HAQ scores between the two groups. So-called mild hemophilia A was associated with a negative effect on physical health-related quality of life, contributed to by joint damage as a result of prior bleeding.
OBJECTIVES: To compare the health-related quality of life among adult males affected with mild hemophilia A due to the same mutation (Val2016ala) to that of unaffected age and sex matched controls from the same general population. METHODS: The Short-Form 36 (SF-36) and Health Assessment Questionnaire (HAQ) were used to measure health-related quality of life and physical function. Other measures included bleeding history, a measure of joint damage, body mass index, age, and viral infection status. Cross-sectional data were collected through research clinics and a retrospective chart audit over a two-year period. RESULTS AND CONCLUSIONS: The study included 47 affected males and 33 controls. The affected males had a higher level of co-morbidity, prior bleeding, and existing joint damage than controls. With the exception of the social function and health transition scales, mean scores for each of the SF-36 domains were worse among affected males. Mean differences were more than a clinically important five points in five of eight domains, with the general health scale showing more than a 10-point difference. Despite the degree of difference noted, only two of the differences were statistically significant (general health and role emotional scales) because of the small sample size and considerable individual variation in SF-36 scale scores. Multiple regression analyses suggested existing joint damage and presence of heart disease as the strongest associates of lower physical health-related quality of life. Joint damage in turn was partly related to prior hemarthroses. Compared to the Canadian population, affected males had lower scores in six out of eight SF-36 domains as well as the physical component summary score. There were no significant differences found in the HAQ scores between the two groups. So-called mild hemophilia A was associated with a negative effect on physical health-related quality of life, contributed to by joint damage as a result of prior bleeding.
Authors: Annette von Drygalski; Nicholas A Kolaitis; Ricki Bettencourt; Jaclyn Bergstrom; R Kruse-Jarres; Doris V Quon; Christina Wassel; Ming C Li; Jill Waalen; Darlene J Elias; Laurent O Mosnier; Matthew Allison Journal: Hypertension Date: 2013-04-29 Impact factor: 10.190
Authors: Behrouz Parhampour; Mehdi Dadgoo; Giti Torkaman; Roya Ravanbod; Tina Delsouz Bahri; Mohammad Jazebi; Seyed Mehdi Mohsenipour; Behnoosh Vasaghi-Gharamaleki Journal: Med J Islam Repub Iran Date: 2021-06-01
Authors: Peter M ten Klooster; Martijn A H Oude Voshaar; Barbara Gandek; Matthias Rose; Jakob B Bjorner; Erik Taal; Cees A W Glas; Piet L C M van Riel; Mart A F J van de Laar Journal: Health Qual Life Outcomes Date: 2013-11-15 Impact factor: 3.186
Authors: Jamie O'Hara; Shaun Walsh; Charlotte Camp; Giuseppe Mazza; Liz Carroll; Christina Hoxer; Lars Wilkinson Journal: Health Qual Life Outcomes Date: 2018-05-02 Impact factor: 3.186
Authors: Patricia A M Kracht; Faydra I Lieveld; Linde M Amelung; Carina J R Verstraete; Eveline P Mauser-Bunschoten; Joep de Bruijne; Peter D Siersema; Andy I M Hoepelman; Joop E Arends; Karel J van Erpecum Journal: Infect Dis Ther Date: 2018-08-03