Literature DB >> 18282695

Applications for ROCK kinase inhibition.

Michael F Olson1.   

Abstract

ROCK kinases, which play central roles in the organization of the actin cytoskeleton, are tantalizing targets for the treatment of human diseases. Deletion of ROCK I in mice revealed a role in the pathophysiological responses to high blood pressure, and validated ROCK inhibition for the treatment of specific types of cardiovascular disease. To date, the only ROCK inhibitor employed clinically in humans is fasudil, which has been used safely in Japan since 1995 for the treatment of cerebral vasospasm. Clinical trials, mostly focusing on the cardiovascular system, have uncovered beneficial effects of fasudil for additional indications. Intriguing recent findings also suggest significant potential for ROCK inhibitors in the production and implantation of stem cells for disease therapies.

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Year:  2008        PMID： 18282695      PMCID： PMC2377343          DOI： 10.1016/j.ceb.2008.01.002

Source DB:  PubMed          Journal:  Curr Opin Cell Biol        ISSN： 0955-0674            Impact factor:   8.382


  54 in total

1.  Rho kinase inhibition initiates apoptosis in human airway epithelial cells.

Authors:  Michael Moore; Bertha A Marroquin; Wendy Gugliotta; Roberta Tse; Steven R White
Journal:  Am J Respir Cell Mol Biol       Date:  2003-08-21       Impact factor: 6.914

2.  Possible involvement of Rho-kinase in the pathogenesis of hypertension in humans.

Authors:  A Masumoto; Y Hirooka; H Shimokawa; K Hironaga; S Setoguchi; A Takeshita
Journal:  Hypertension       Date:  2001-12-01       Impact factor: 10.190

3.  Suppression of coronary artery spasm by the Rho-kinase inhibitor fasudil in patients with vasospastic angina.

Authors:  Akihiro Masumoto; Masahiro Mohri; Hiroaki Shimokawa; Lemmy Urakami; Makoto Usui; Akira Takeshita
Journal:  Circulation       Date:  2002-04-02       Impact factor: 29.690

4.  Y-27632 prevents tubulointerstitial fibrosis in mouse kidneys with unilateral ureteral obstruction.

Authors:  Katsuyuki Nagatoya; Toshiki Moriyama; Noritaka Kawada; Masanobu Takeji; Susumu Oseto; Takahiro Murozono; Akio Ando; Enyu Imai; Masatsugu Hori
Journal:  Kidney Int       Date:  2002-05       Impact factor: 10.612

5.  Membrane blebbing during apoptosis results from caspase-mediated activation of ROCK I.

Authors:  M L Coleman; E A Sahai; M Yeo; M Bosch; A Dewar; M F Olson
Journal:  Nat Cell Biol       Date:  2001-04       Impact factor: 28.824

6.  Targeted disruption of the mouse rho-associated kinase 2 gene results in intrauterine growth retardation and fetal death.

Authors:  Dean Thumkeo; Jeongsin Keel; Toshimasa Ishizaki; Masaya Hirose; Kimiko Nonomura; Hiroko Oshima; Masanobu Oshima; Makoto M Taketo; Shuh Narumiya
Journal:  Mol Cell Biol       Date:  2003-07       Impact factor: 4.272

7.  Usefulness of fasudil, a Rho-kinase inhibitor, to treat intractable severe coronary spasm after coronary artery bypass surgery.

Authors:  Kousuke Inokuchi; Akira Ito; Yoshihiro Fukumoto; Tetsuya Matoba; Akira Shiose; Takahiro Nishida; Munetaka Masuda; Shigeki Morita; Hiroaki Shimokawa
Journal:  J Cardiovasc Pharmacol       Date:  2004-09       Impact factor: 3.105

8.  Rho-kinase inhibition reduces neointima formation after vascular injury by enhancing Bax expression and apoptosis.

Authors:  Rei Shibata; Hisashi Kai; Yukihiko Seki; Ken Kusaba; Kiyoko Takemiya; Mitsuhisa Koga; Ali Jalalidin; Keisuke Tokuda; Nobuhiro Tahara; Hiroshi Niiyama; Tsuyoshi Nagata; Fumitaka Kuwahara; Tsutomu Imaizumi
Journal:  J Cardiovasc Pharmacol       Date:  2003-12       Impact factor: 3.105

9.  ROCK inhibitor (Y27632) increases apoptosis and disrupts the actin cortical mat in embryonic avian corneal epithelium.

Authors:  Kathy K H Svoboda; Petra Moessner; Tamara Field; Jesus Acevedo
Journal:  Dev Dyn       Date:  2004-03       Impact factor: 3.780

10.  The GTP binding proteins Gem and Rad are negative regulators of the Rho-Rho kinase pathway.

Authors:  Yvona Ward; Seow-Fong Yap; V Ravichandran; Fumio Matsumura; Masaaki Ito; Beth Spinelli; Kathleen Kelly
Journal:  J Cell Biol       Date:  2002-04-15       Impact factor: 10.539
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  158 in total

1.  Topical Rho-Associated Kinase Inhibitor, Y27632, Accelerates Corneal Endothelial Regeneration in a Canine Cryoinjury Model.

Authors:  Hidetaka Miyagi; Soohyun Kim; Jennifer Li; Christopher J Murphy; Sara M Thomasy
Journal:  Cornea       Date:  2019-03       Impact factor: 2.651

2.  Elaborate ligand-based modeling reveal new submicromolar Rho kinase inhibitors.

Authors:  Rand Shahin; Saja Alqtaishat; Mutasem O Taha
Journal:  J Comput Aided Mol Des       Date:  2011-12-14       Impact factor: 3.686

3.  Rho kinases (ROCKs) in sepsis-induced acute lung injury.

Authors:  Ravin Narain
Journal:  J Thorac Dis       Date:  2012-02       Impact factor: 2.895

4.  Effect of small molecule supplements during in vitro culture of mouse zygotes and parthenogenetic embryos on hypoblast formation and stem cell derivation.

Authors:  K Versieren; M Van der Jeught; T O'Leary; G Duggal; J Gerris; S Chuva de Sousa Lopes; B Heindryckx; P De Sutter
Journal:  Stem Cell Rev Rep       Date:  2012-12       Impact factor: 5.739

Review 5.  The ROCK signaling and breast cancer metastasis.

Authors:  Sijin Liu
Journal:  Mol Biol Rep       Date:  2010-07-03       Impact factor: 2.316

6.  Caspase-activated ROCK-1 allows erythroblast terminal maturation independently of cytokine-induced Rho signaling.

Authors:  A-S Gabet; S Coulon; A Fricot; J Vandekerckhove; Y Chang; J-A Ribeil; L Lordier; Y Zermati; V Asnafi; Z Belaid; N Debili; W Vainchenker; B Varet; O Hermine; G Courtois
Journal:  Cell Death Differ       Date:  2010-11-12       Impact factor: 15.828

7.  Effect of Rho-kinase Inhibitor, Y27632, on Porcine Corneal Endothelial Cell Culture, Inflammation and Immune Regulation.

Authors:  Whayoung Lee; Yuko Miyagawa; Cassandra Long; Matthew Zhang; David K C Cooper; Hidetaka Hara
Journal:  Ocul Immunol Inflamm       Date:  2015-10-16       Impact factor: 3.070

8.  Cathepsin B and phospo-JNK in relation to ongoing apoptosis after transient focal cerebral ischemia in the rat.

Authors:  Zhi Bo Zhang; Zhi Gang Li
Journal:  Neurochem Res       Date:  2012-01-22       Impact factor: 3.996

9.  ROCK inhibition enhances the recovery and growth of cryopreserved human embryonic stem cells and human induced pluripotent stem cells.

Authors:  David A Claassen; Michelle M Desler; Angie Rizzino
Journal:  Mol Reprod Dev       Date:  2009-08       Impact factor: 2.609

10.  ABL2/ARG tyrosine kinase mediates SEMA3F-induced RhoA inactivation and cytoskeleton collapse in human glioma cells.

Authors:  Akio Shimizu; Akiko Mammoto; Joseph E Italiano; Elke Pravda; Andrew C Dudley; Donald E Ingber; Michael Klagsbrun
Journal:  J Biol Chem       Date:  2008-07-25       Impact factor: 5.157
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