Literature DB >> 18277970

Expanding chemical biology of 2-oxoglutarate oxygenases.

Christoph Loenarz1, Christopher J Schofield.   

Abstract

Beyond established roles in collagen biosynthesis, hypoxic signaling and fatty acid metabolism, recent reports have now revealed roles for human 2-oxoglutarate-dependent oxygenases in histone and nucleic acid demethylation and in signaling protein hydroxylation. The emerging role of these oxygenases in enabling a multiplicity of histone modifications has some analogy with their role in enabling structural diversity in secondary metabolism.

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Year:  2008        PMID： 18277970     DOI： 10.1038/nchembio0308-152

Source DB:  PubMed          Journal:  Nat Chem Biol        ISSN： 1552-4450            Impact factor:   15.040


  222 in total

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8.  Hydroxylation of the eukaryotic ribosomal decoding center affects translational accuracy.

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