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Literature DB >> 22306135

Alterations of metabolic genes and metabolites in cancer.

Eric K Oermann¹, Jing Wu, Kun-Liang Guan, Yue Xiong.

Abstract

Altered metabolic regulation has long been observed in human cancer and broadly used in the clinic for tumor detection. Two recent findings--the direct regulation of metabolic enzymes by frequently mutated cancer genes and frequent mutations of several metabolic enzymes themselves in cancer--have renewed interest in cancer metabolism. Supporting a causative role of altered metabolic enzymes in tumorigenesis, abnormal levels of several metabolites have been found to play a direct role in cancer development. The alteration of metabolic genes and metabolites offer not only new biomarkers for diagnosis and prognosis, but also potential new targets for cancer therapy.

Entities: CellLine Chemical Disease Gene Species

Mesh：

Substances：
Glutamine
Glucose

Year: 2012 PMID： 22306135 PMCID： PMC3351496 DOI： 10.1016/j.semcdb.2012.01.013

Source DB: PubMed Journal: Semin Cell Dev Biol ISSN： 1084-9521 Impact factor: 7.727

102 in total

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Authors: O WARBURG
Journal: Science Date: 1956-02-24 Impact factor: 47.728

3. Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA.

Authors: Yu-Fei He; Bin-Zhong Li; Zheng Li; Peng Liu; Yang Wang; Qingyu Tang; Jianping Ding; Yingying Jia; Zhangcheng Chen; Lin Li; Yan Sun; Xiuxue Li; Qing Dai; Chun-Xiao Song; Kangling Zhang; Chuan He; Guo-Liang Xu
Journal: Science Date: 2011-08-04 Impact factor: 47.728

4. The L- and R-type isozymes of rat pyruvate kinase are produced from a single gene by use of different promoters.

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Journal: J Biol Chem Date: 1987-10-15 Impact factor: 5.157

5. Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer.

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Journal: Nat Genet Date: 2002-02-25 Impact factor: 38.330

Review 6. IDH mutations in glioma and acute myeloid leukemia.

Authors: Lenny Dang; Shengfang Jin; Shinsan M Su
Journal: Trends Mol Med Date: 2010-08-05 Impact factor: 11.951

7. Missense mutations in fumarate hydratase in multiple cutaneous and uterine leiomyomatosis and renal cell cancer.

Authors: N Afrina Alam; Simon Olpin; Andrew Rowan; David Kelsell; Irene M Leigh; Ian P M Tomlinson; Todd Weaver
Journal: J Mol Diagn Date: 2005-10 Impact factor: 5.568

8. Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha.

Authors: Shimin Zhao; Yan Lin; Wei Xu; Wenqing Jiang; Zhengyu Zha; Pu Wang; Wei Yu; Zhiqiang Li; Lingling Gong; Yingjie Peng; Jianping Ding; Qunying Lei; Kun-Liang Guan; Yue Xiong
Journal: Science Date: 2009-04-10 Impact factor: 47.728

9. Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases.

Authors: Wei Xu; Hui Yang; Ying Liu; Ying Yang; Ping Wang; Se-Hee Kim; Shinsuke Ito; Chen Yang; Pu Wang; Meng-Tao Xiao; Li-xia Liu; Wen-qing Jiang; Jing Liu; Jin-ye Zhang; Bin Wang; Stephen Frye; Yi Zhang; Yan-hui Xu; Qun-ying Lei; Kun-Liang Guan; Shi-min Zhao; Yue Xiong
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43 in total

1. Targeting cancer metabolism.

Authors: Beverly A Teicher; W Marston Linehan; Lee J Helman
Journal: Clin Cancer Res Date: 2012-10-15 Impact factor: 12.531

2. Myc-mediated SDHA acetylation triggers epigenetic regulation of gene expression and tumorigenesis.

Authors: Shi-Ting Li; Shengqi Shen; Yongping Cai; Songge Xing; Gongwei Wu; Zetan Jiang; Yijie Hao; Mengqiu Yuan; Nana Wang; Lianbang Zhu; Ronghui Yan; Dongdong Yang; Lin Wang; Zhaoji Liu; Xin Hu; Rongbin Zhou; Kun Qu; Ailing Li; Xiaotao Duan; Huafeng Zhang; Ping Gao
Journal: Nat Metab Date: 2020-03-16

10. Exploiting Electrode Nanoconfinement to Investigate the Catalytic Properties of Isocitrate Dehydrogenase (IDH1) and a Cancer-Associated Variant.

Authors: Ryan A Herold; Raphael Reinbold; Clare F Megarity; Martine I Abboud; Christopher J Schofield; Fraser A Armstrong
Journal: J Phys Chem Lett Date: 2021-06-25 Impact factor: 6.475

Alterations of metabolic genes and metabolites in cancer.

1. On respiratory impairment in cancer cells.

2. On the origin of cancer cells.

3. Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA.

4. The L- and R-type isozymes of rat pyruvate kinase are produced from a single gene by use of different promoters.

5. Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer.

Review 6. IDH mutations in glioma and acute myeloid leukemia.

7. Missense mutations in fumarate hydratase in multiple cutaneous and uterine leiomyomatosis and renal cell cancer.

8. Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha.

9. Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases.

10. Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1.

1. Targeting cancer metabolism.

2. Myc-mediated SDHA acetylation triggers epigenetic regulation of gene expression and tumorigenesis.

Review 3. Nutrient sensing, metabolism, and cell growth control.

4. Acetoacetate Accelerates Muscle Regeneration and Ameliorates Muscular Dystrophy in Mice.

Review 5. Targeting cancer's metabolic co-dependencies: A landscape shaped by genotype and tissue context.

Review 6. Interplay between Metabolism and Epigenetics: A Nuclear Adaptation to Environmental Changes.

Review 7. Metabolic mechanisms of epigenetic regulation.

8. R-2-hydroxyglutarate as the key effector of IDH mutations promoting oncogenesis.

9. Saccharomyces cerevisiae DNA ligase IV supports imprecise end joining independently of its catalytic activity.

10. Exploiting Electrode Nanoconfinement to Investigate the Catalytic Properties of Isocitrate Dehydrogenase (IDH1) and a Cancer-Associated Variant.