| Literature DB >> 18275133 |
Shirley A Brunton1, John H A Stibbard, Lee L Rubin, Lawrence I Kruse, Oivin M Guicherit, Edward A Boyd, Steven Price.
Abstract
A small family of phenyl quinazolinone ureas is reported as potent modulators of Hedgehog protein function. Preliminary SAR studies of the urea substituent led to a nanomolar Hedgehog antagonist.Entities:
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Year: 2008 PMID： 18275133 DOI： 10.1021/jm070694n
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446