| Literature DB >> 17420097 |
Peng Wei1, Jia Liu, Hao-Li Zhou, Zhi-Tong Han, Qing-Ying Wu, Jiang-Xia Pang, Su Liu, Ting-Hua Wang.
Abstract
This study evaluated the therapeutic effect of neural stem cells (NSCs) transplanted into Parkinson's disease (PD) rats. NSCs were identified in vitro, then engrafted into the striatum of the PD rats. The rotational behavior was evaluated 1, 2, 4 and 6 weeks. A significant rotational behavior improvement was observed in PD rats subjected to cell transplantation. Transplanted NSCs not only express Nerve growth factor and Neurotrophin-3 in vitro, but also survive and partly differentiate into tyrosine hydroxylase (TH) positive cells in vivo. The results show that NSCs could be effective for PD treatment and the mechanisms might involve the neurotrophin expression and the neural differentiation.Entities:
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Year: 2007 PMID： 17420097 DOI： 10.1016/j.neulet.2007.03.046
Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046