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Literature DB >> 18272545

Autophagy as an important process in gut homeostasis and Crohn's disease pathogenesis.

Ramnik J Xavier¹, Alan Huett, John D Rioux.

Abstract

Entities: Disease

Mesh：

Substances：

Year: 2008 PMID： 18272545 PMCID： PMC2735854 DOI： 10.1136/gut.2007.134254

Source DB: PubMed Journal: Gut ISSN： 0017-5749 Impact factor: 23.059

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44 in total

1. Autophagy-dependent viral recognition by plasmacytoid dendritic cells.

Authors: Heung Kyu Lee; Jennifer M Lund; Balaji Ramanathan; Noboru Mizushima; Akiko Iwasaki
Journal: Science Date: 2007-02-01 Impact factor: 47.728

2. Macrophage activation downregulates the degradative capacity of the phagosome.

Authors: Robin M Yates; Albin Hermetter; Gregory A Taylor; David G Russell
Journal: Traffic Date: 2007-03 Impact factor: 6.215

Review 3. IRG proteins: key mediators of interferon-regulated host resistance to intracellular pathogens.

Authors: Gregory A Taylor
Journal: Cell Microbiol Date: 2007-03-13 Impact factor: 3.715

4. Lysosomal killing of Mycobacterium mediated by ubiquitin-derived peptides is enhanced by autophagy.

Authors: Sylvie Alonso; Kevin Pethe; David G Russell; Georgiana E Purdy
Journal: Proc Natl Acad Sci U S A Date: 2007-03-26 Impact factor: 11.205

5. Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis.

Authors: John D Rioux; Ramnik J Xavier; Kent D Taylor; Mark S Silverberg; Philippe Goyette; Alan Huett; Todd Green; Petric Kuballa; M Michael Barmada; Lisa Wu Datta; Yin Yao Shugart; Anne M Griffiths; Stephan R Targan; Andrew F Ippoliti; Edmond-Jean Bernard; Ling Mei; Dan L Nicolae; Miguel Regueiro; L Philip Schumm; A Hillary Steinhart; Jerome I Rotter; Richard H Duerr; Judy H Cho; Mark J Daly; Steven R Brant
Journal: Nat Genet Date: 2007-04-15 Impact factor: 38.330

6. Cis1/Atg31 is required for autophagosome formation in Saccharomyces cerevisiae.

Authors: Yukiko Kabeya; Tomoko Kawamata; Kuninori Suzuki; Yoshinori Ohsumi
Journal: Biochem Biophys Res Commun Date: 2007-03-07 Impact factor: 3.575

7. Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4.

Authors: Ruth Scherz-Shouval; Elena Shvets; Ephraim Fass; Hagai Shorer; Lidor Gil; Zvulun Elazar
Journal: EMBO J Date: 2007-03-08 Impact factor: 11.598

8. Ability of SPI2 mutant of S. typhi to effectively induce antibody responses to the mucosal antigen enterotoxigenic E. coli heat labile toxin B subunit after oral delivery to humans.

Authors: S Khan; S Chatfield; R Stratford; J Bedwell; M Bentley; S Sulsh; R Giemza; S Smith; E Bongard; C A Cosgrove; J Johnson; G Dougan; G E Griffin; J Makin; D J M Lewis
Journal: Vaccine Date: 2007-03-21 Impact factor: 3.641

9. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.

Authors:
Journal: Nature Date: 2007-06-07 Impact factor: 49.962

10. Small molecules enhance autophagy and reduce toxicity in Huntington's disease models.

Authors: Sovan Sarkar; Ethan O Perlstein; Sara Imarisio; Sandra Pineau; Axelle Cordenier; Rebecca L Maglathlin; John A Webster; Timothy A Lewis; Cahir J O'Kane; Stuart L Schreiber; David C Rubinsztein
Journal: Nat Chem Biol Date: 2007-05-07 Impact factor: 15.040

22 in total

Autophagy as an important process in gut homeostasis and Crohn's disease pathogenesis.

1. Autophagy-dependent viral recognition by plasmacytoid dendritic cells.

2. Macrophage activation downregulates the degradative capacity of the phagosome.

Review 3. IRG proteins: key mediators of interferon-regulated host resistance to intracellular pathogens.

4. Lysosomal killing of Mycobacterium mediated by ubiquitin-derived peptides is enhanced by autophagy.

5. Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis.

6. Cis1/Atg31 is required for autophagosome formation in Saccharomyces cerevisiae.

7. Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4.

8. Ability of SPI2 mutant of S. typhi to effectively induce antibody responses to the mucosal antigen enterotoxigenic E. coli heat labile toxin B subunit after oral delivery to humans.

9. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.

10. Small molecules enhance autophagy and reduce toxicity in Huntington's disease models.

1. The JAK2 variant rs10758669 in Crohn's disease: altering the intestinal barrier as one mechanism of action.

2. Intestinal epithelial cells with impaired autophagy lose their adhesive capacity in the presence of TNF-α.

3. Regulation of macrophage motility by Irgm1.

4. Lack of association of the autophagy-related gene polymorphism ATG16L1 rs2241880 in RA predisposition.

5. Moderate hypoxia potentiates interleukin-1β production in activated human macrophages.

6. T300A polymorphism of ATG16L1 and susceptibility to inflammatory bowel diseases: a meta-analysis.

7. The neutrophil respiratory burst and bacterial digestion in Crohn's disease.

Review 8. The role of the macrophage in sentinel responses in intestinal immunity.

9. ATG16L1 and NOD2 polymorphisms enhance phagocytosis in monocytes of Crohn's disease patients.

10. On the level: IRGM gene function is all about expression.