Literature DB >> 1827254

Staurosporine both activates and inhibits serine/threonine kinases in human platelets.

M Kocher1, K J Clemetson.   

Abstract

The effects of staurosporine on a selection of protein kinases were investigated with thrombin-stimulated and control human blood platelets. The results demonstrate that staurosporine (1 microM) can lead to activation of certain protein kinases in intact platelets and has a general inhibitory effect on the renaturable protein kinases in vitro. New candidates for protein kinases involved in signal transduction are identified.

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Year:  1991        PMID： 1827254      PMCID： PMC1150052          DOI： 10.1042/bj2750301

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  29 in total

1.  Staurosporine-induced neurite outgrowth in PC12h cells.

Authors:  S Hashimoto; A Hagino
Journal:  Exp Cell Res       Date:  1989-10       Impact factor: 3.905

2.  Staurosporine inhibits tyrosine-specific protein kinase activity of Rous sarcoma virus transforming protein p60.

Authors:  H Nakano; E Kobayashi; I Takahashi; T Tamaoki; Y Kuzuu; H Iba
Journal:  J Antibiot (Tokyo)       Date:  1987-05       Impact factor: 2.649

3.  Phosphorylation-dependent and -independent pathways of platelet aggregation.

Authors:  S P Watson; S Hambleton
Journal:  Biochem J       Date:  1989-03-01       Impact factor: 3.857

4.  Staurosporine, a potent inhibitor of phospholipid/Ca++dependent protein kinase.

Authors:  T Tamaoki; H Nomoto; I Takahashi; Y Kato; M Morimoto; F Tomita
Journal:  Biochem Biophys Res Commun       Date:  1986-03-13       Impact factor: 3.575

5.  Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

Authors:  U K Laemmli
Journal:  Nature       Date:  1970-08-15       Impact factor: 49.962

6.  Staurosporine inhibits the respiratory burst and induces exocytosis in human neutrophils.

Authors:  B Dewald; M Thelen; M P Wymann; M Baggiolini
Journal:  Biochem J       Date:  1989-12-15       Impact factor: 3.857

7.  Comparison of protein kinase C functional assays to clarify mechanisms of inhibitor action.

Authors:  T Nakadate; A Y Jeng; P M Blumberg
Journal:  Biochem Pharmacol       Date:  1988-04-15       Impact factor: 5.858

8.  Contrasting actions of staurosporine, a protein kinase C inhibitor, on human neutrophils and primary mouse epidermal cells.

Authors:  T Sako; A I Tauber; A Y Jeng; S H Yuspa; P M Blumberg
Journal:  Cancer Res       Date:  1988-08-15       Impact factor: 12.701

9.  The protein kinase inhibitor staurosporine, like phorbol esters, induces the association of protein kinase C with membranes.

Authors:  M Wolf; M Baggiolini
Journal:  Biochem Biophys Res Commun       Date:  1988-08-15       Impact factor: 3.575

10.  The action of the protein kinase C inhibitor, staurosporine, on human platelets. Evidence against a regulatory role for protein kinase C in the formation of inositol trisphosphate by thrombin.

Authors:  S P Watson; J McNally; L J Shipman; P P Godfrey
Journal:  Biochem J       Date:  1988-01-15       Impact factor: 3.857
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  7 in total

Review 1.  The role of protein kinase C and its neuronal substrates dephosphin, B-50, and MARCKS in neurotransmitter release.

Authors:  P J Robinson
Journal:  Mol Neurobiol       Date:  1991       Impact factor: 5.590

2.  Inhibition of neuronal cyclin-dependent kinase-5 by staurosporine and purine analogs is independent of activation by Munc-18.

Authors:  K T Shetty; N Amin; P Grant; R W Albers; H C Pant
Journal:  Neurochem Res       Date:  1996-05       Impact factor: 3.996

3.  Inhibition of mitogen-activated protein kinase kinase does not impair primary activation of human platelets.

Authors:  A G Börsch-Haubold; R M Kramer; S P Watson
Journal:  Biochem J       Date:  1996-08-15       Impact factor: 3.857

4.  Regulation of phospholipase D by sphingosine involves both protein kinase C-dependent and -independent mechanisms in NIH 3T3 fibroblasts.

Authors:  Z Kiss; E Deli
Journal:  Biochem J       Date:  1992-12-15       Impact factor: 3.857

5.  Apical and basolateral Na/H exchange in cultured murine proximal tubule cells (MCT): effect of parathyroid hormone (PTH).

Authors:  B Mrkic; J Forgo; H Murer; C Helmle-Kolb
Journal:  J Membr Biol       Date:  1992-12       Impact factor: 1.843

6.  Activation of protein kinase C is not an absolute requirement for amylase release from permeabilized rat pancreatic acini.

Authors:  A J O'Sullivan; J D Jamieson
Journal:  Biochem J       Date:  1992-07-15       Impact factor: 3.857

7.  Activation of phospholipase C and protein kinase C has little involvement in ADP-induced primary aggregation of human platelets: effects of diacylglycerols, the diacylglycerols, the diacylglycerol kinase inhibitor R59022, staurosporine and okadaic acid.

Authors:  M A Packham; A A Livne; D H Ruben; M L Rand
Journal:  Biochem J       Date:  1993-03-15       Impact factor: 3.857
  7 in total

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