Literature DB >> 3457562

Staurosporine, a potent inhibitor of phospholipid/Ca++dependent protein kinase.

T Tamaoki, H Nomoto, I Takahashi, Y Kato, M Morimoto, F Tomita.   

Abstract

Staurosporine, microbial alkaloid which has been known to have antifungal activity was found to inhibit markedly phospholipid/Ca++dependent protein kinase (protein kinase C) from rat brain, with an IC50 value of 2.7 nM. However, it had little effect on the binding of 3H-phorbol-12, 13-dibutyrate (PDBu) to protein kinase C. The inhibition of protein kinase C was not competitive with phospholipid. This compound also showed the strong cytotoxic effect on the growth of HeLa S3 cells, with an IC50 value of 4 X 10(-12)M under the condition of 72 hr-exposure.

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Year:  1986        PMID： 3457562     DOI： 10.1016/0006-291x(86)90008-2

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  486 in total

1.  Reconstitution of muscarinic modulation of the KCNQ2/KCNQ3 K(+) channels that underlie the neuronal M current.

Authors:  M S Shapiro; J P Roche; E J Kaftan; H Cruzblanca; K Mackie; B Hille
Journal:  J Neurosci       Date:  2000-03-01       Impact factor: 6.167

2.  Ligation of Fc receptor of macrophages stimulates protein kinase C and anti-leishmanial activity.

Authors:  D Dasgupta; P Chakraborty; M K Basu
Journal:  Mol Cell Biochem       Date:  2000-06       Impact factor: 3.396

3.  An oxidized nucleotide affects DNA replication through activation of protein kinases in Xenopus egg lysates.

Authors:  Toshinori Kai; Rieko Matsunaga; Masami Eguchi; Hiroyuki Kamiya; Hiroshi Kasai; Motoshi Suzuki; Shunji Izuta
Journal:  Nucleic Acids Res       Date:  2002-01-15       Impact factor: 16.971

4.  Establishment of a tetraploid Meth-A cell line through polyploidization by demecolcine but not by staurosporine, K-252A and paclitaxel.

Authors:  K Fujikawa-Yamamoto; S Wang; H Yamagishi; C Ohdoi; H Murano; T Ikeda
Journal:  Cell Prolif       Date:  2001-08       Impact factor: 6.831

5.  Partial purification and characterization of a Ca(2+)-dependent protein kinase from pea nuclei.

Authors:  H Li; M Dauwalder; S J Roux
Journal:  Plant Physiol       Date:  1991       Impact factor: 8.340

6.  Coordinate regulation of glutathione biosynthesis and release by Nrf2-expressing glia potently protects neurons from oxidative stress.

Authors:  Andy Y Shih; Delinda A Johnson; Gloria Wong; Andrew D Kraft; Lei Jiang; Heidi Erb; Jeffrey A Johnson; Timothy H Murphy
Journal:  J Neurosci       Date:  2003-04-15       Impact factor: 6.167

7.  Analysis of protein kinase A activity in insulin-secreting cells using a cell-penetrating protein substrate and capillary electrophoresis.

Authors:  Femina Rauf; Yiding Huang; Thusitha P Muhandiramlage; Craig A Aspinwall
Journal:  Anal Bioanal Chem       Date:  2010-05-12       Impact factor: 4.142

8.  Inhibition of carbachol stimulated acid secretion by interleukin 1beta in rabbit parietal cells requires protein kinase C.

Authors:  I L Beales; J Calam
Journal:  Gut       Date:  2001-06       Impact factor: 23.059

9.  cis-Fatty acids, which activate protein kinase C, attenuate Na+ and Ca2+ currents in mouse neuroblastoma cells.

Authors:  D J Linden; A Routtenberg
Journal:  J Physiol       Date:  1989-12       Impact factor: 5.182

10.  Down-regulation of protein kinase C potentiates angiotensin II-stimulated polyphosphoinositide hydrolysis in vascular smooth-muscle cells.

Authors:  J Pfeilschifter; M Ochsner; S Whitebread; M De Gasparo
Journal:  Biochem J       Date:  1989-08-15       Impact factor: 3.857
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