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Literature DB >> 18272493

Wound angiogenesis as a function of tissue oxygen tension: a mathematical model.

Richard C Schugart¹, Avner Friedman, Rui Zhao, Chandan K Sen.

Abstract

Wound healing represents a well orchestrated reparative response that is induced by injuries. Angiogenesis plays a central role in wound healing. In this work, we sought to develop the first mathematical model directed at addressing the role of tissue oxygen tension on cutaneous wound healing. Key components of the developed model include capillary tips, capillary sprouts, fibroblasts, inflammatory cells, chemoattractants, oxygen, and the extracellular matrix. The model consists of a system of nonlinear partial differential equations describing the interactions in space and time of these variables. The simulated results agree with the reported literature on the biology of wound healing. The proposed model represents a useful tool to analyze strategies for improved healing and generate a hypothesis for experimental testing.

Entities: Chemical Disease

Mesh：

Substances：

Year: 2008 PMID： 18272493 PMCID： PMC2268187 DOI： 10.1073/pnas.0711642105

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

60 in total

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Authors: Anette Raa; Christine Stansberg; Vidar M Steen; Rolf Bjerkvig; Rolf K Reed; Linda E B Stuhr
Journal: BMC Cancer Date: 2007-01-30 Impact factor: 4.430

Wound angiogenesis as a function of tissue oxygen tension: a mathematical model.

1. A model of wound-healing angiogenesis in soft tissue.

Review 2. The role of extracellular matrix proteins in the control of phagocytosis.

3. Discoidin domain receptor 2 regulates fibroblast proliferation and migration through the extracellular matrix in association with transcriptional activation of matrix metalloproteinase-2.

4. Oxygen diffusion in tumour capillary networks.

5. Hyperoxia and angiogenesis.

6. Biphasic oxygen kinetics of cellular respiration and linear oxygen dependence of antimycin A inhibited oxygen consumption.

7. Strategies to enhance capillary formation inside biomaterials: a computational study.

8. A mechanochemical model for adult dermal wound contraction and the permanence of the contracted tissue displacement profile.

9. Hyperoxia retards growth and induces apoptosis and loss of glands and blood vessels in DMBA-induced rat mammary tumors.

10. Migration of individual microvessel endothelial cells: stochastic model and parameter measurement.

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