Literature DB >> 18271552

Butyrolactone I derivatives from Aspergillus terreus carrying an unusual sulfate moiety.

Xuemei Niu1, Hans-Martin Dahse, Klaus-Dieter Menzel, Olivier Lozach, Grit Walther, Laurent Meijer, Susanne Grabley, Isabel Sattler.   

Abstract

In our ongoing search for new bioactive metabolites from microbial resources, Aspergillus terreus (HKI0499) was examined by chemical metabolite profiling. Together with the known butyrolactone I ( 3), the unusual sulfate derivatives butyrolactone I 3-sulfate ( 1) and butyrolactone I 4''-sulfate ( 2) were discovered. The chemical structures were determined by NMR and MS data analyses. All compounds were tested on CDK1/cyclin B, CDK5/p25, DYRK1A, CK1, and GSK-3alpha/beta kinases; compounds 2 and 3 were also evaluated for their cytotoxic and antiproliferative activities. Butyrolactone I 3-sulfate ( 1) exhibited specific inhibitory activity against CDK1/cyclin B and CDK5/p25, yet 15-30-fold less than butyrolactone I ( 3). Likewise, butyrolactone I 3-sulfate ( 1) exhibited moderate cytotoxicity solely against HeLa cells (CC 50 = 80.7 microM).

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Year:  2008        PMID： 18271552     DOI： 10.1021/np070341r

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  9 in total

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5.  Butyrolactone-I from Coral-Derived Fungus Aspergillus terreus Attenuates Neuro-Inflammatory Response via Suppression of NF-κB Pathway in BV-2 Cells.

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6.  Cyclin-Dependent Kinase 5 Inhibitor Butyrolactone I Elicits a Partial Agonist Activity of Peroxisome Proliferator-Activated Receptor γ.

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Journal:  Mar Drugs       Date:  2021-10-20       Impact factor: 5.118

9.  Production of Terretonin N and Butyrolactone I by Thermophilic Aspergillus terreus TM8 Promoted Apoptosis and Cell Death in Human Prostate and Ovarian Cancer Cells.

Authors:  Ayman A Ghfar; Mohammad Magdy El-Metwally; Mohamed Shaaban; Sami A Gabr; Nada S Gabr; Marwa S M Diab; Ahmad Aqel; Mohamed A Habila; Wahidah H Al-Qahtani; Mohammad Y Alfaifi; Serag Eldin I Elbehairi; Bayan Ahmed AlJumah
Journal:  Molecules       Date:  2021-05-10       Impact factor: 4.411
  9 in total

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