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Literature DB >> 182702

Cytotoxicity for tumor cells of cationic proteins from human neutrophil granules.

Abstract

Cationic proteins purified from human polymorphonuclear leukocyte granules exert a cytotoxic effect on mammalian tumor cells. This effect is time and concentration dependent, is inhibited by the anionic agent heparin, and is enhanced by preheating the cationic proteins. Other strongly basic proteins (histone, protamine) also exhibited cytotoxic activity. Myeloperoxidase isolated from human leukocytes is cytotoxic when combined with H2O2 and chloride. Under these conditions, the potency of the myeloperoxidase-mediated system is greater than that of the cationic proteins.

Entities: Chemical Disease Gene Species

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Year: 1976 PMID： 182702 PMCID： PMC2109852 DOI： 10.1083/jcb.70.3.719

Source DB: PubMed Journal: J Cell Biol ISSN： 0021-9525 Impact factor: 10.539

34 in total

1. Polymorphonuclear leukocytes in antibody-dependent cellular cytotoxicity.

Authors: R P Gale; J Zighelboim
Journal: J Immunol Date: 1975-03 Impact factor: 5.422

2. Antimicrobial mechanisms in neutrophilic polymorphonuclear leukocytes.

Authors: S J Klebanoff
Journal: Semin Hematol Date: 1975-04 Impact factor: 3.851

3. Cationic proteins from human neutrophil granulocytes. Evidence for their chymotrypsin-like properties.

Authors: R Rindler-Ludwig; H Braunsteiner
Journal: Biochim Biophys Acta Date: 1975-02-27

4. Antibacterial activity of cationic proteins from human granulocytes.

Authors: H Odeberg; I Olsson
Journal: J Clin Invest Date: 1975-11 Impact factor: 14.808

5. Release of basic proteins and lysosomal enzymes from neutrophil leukocytes of the rabbit.

Authors: N S Ranadive; A N Sajnani; K Alimurka; H Z Movat
Journal: Int Arch Allergy Appl Immunol Date: 1973

6. Cationic proteins of human granulocytes. II. Separation of the cationic proteins of the granules of leukemic myeloid cells.

Authors: I Olsson; P Venge
Journal: Blood Date: 1974-08 Impact factor: 22.113

6. Effects of neutrophil elastase and other proteases on porcine aortic endothelial prostaglandin I2 production, adenine nucleotide release, and responses to vasoactive agents.

Authors: E C LeRoy; A Ager; J L Gordon
Journal: J Clin Invest Date: 1984-09 Impact factor: 14.808

7. Cytolytic effect of polylysine on rabbit polymorphonuclear leukocytes.

Authors: J G Elferink
Journal: Inflammation Date: 1985-09 Impact factor: 4.092

8. Hydrogen peroxide producing lactobacilli in women with cervical neoplasia.

Authors: Ho Sun Choi; Ki Min Kim; Chol Hong Kim; Seok Mo Kim; Jong Seok Oh
Journal: Cancer Res Treat Date: 2006-04-30 Impact factor: 4.679

9. Damage to Aspergillus fumigatus and Rhizopus oryzae hyphae by oxidative and nonoxidative microbicidal products of human neutrophils in vitro.

Authors: R D Diamond; R A Clark
Journal: Infect Immun Date: 1982-11 Impact factor: 3.441

10. Mechanisms of attachment of neutrophils to Candida albicans pseudohyphae in the absence of serum, and of subsequent damage to pseudohyphae by microbicidal processes of neutrophils in vitro.

Authors: R D Daimond; R Krzesicki
Journal: J Clin Invest Date: 1978-02 Impact factor: 14.808

Cytotoxicity for tumor cells of cationic proteins from human neutrophil granules.

1. Polymorphonuclear leukocytes in antibody-dependent cellular cytotoxicity.

2. Antimicrobial mechanisms in neutrophilic polymorphonuclear leukocytes.

3. Cationic proteins from human neutrophil granulocytes. Evidence for their chymotrypsin-like properties.

4. Antibacterial activity of cationic proteins from human granulocytes.

5. Release of basic proteins and lysosomal enzymes from neutrophil leukocytes of the rabbit.

6. Cationic proteins of human granulocytes. II. Separation of the cationic proteins of the granules of leukemic myeloid cells.

7. Cationic proteins of human granulocytes. IV. Esterase activity.

8. Peroxidase-H2O2-halide system: Cytotoxic effect on mammalian tumor cells.

9. Hemolysis and iodination of erythrocyte components by a myeloperoxidase-mediated system.

10. Neutrophil-mediated tumor cell cytotoxicity: role of the peroxidase system.

1. Changes of plasma membrane permeability in neutrophils treated with polycations.

2. Protamine sulfate-induced enzyme secretion from rabbit neutrophils.

3. Permeabilization and calcium-dependent activation of rabbit polymorphonuclear leukocytes by poly-L-arginine.

4. Differential contribution of chemotaxins and opsonins to neutrophil-mediated killing of Schistosoma mansoni larvae.

5. Neutrophil-induced injury of rat pulmonary alveolar epithelial cells.

6. Effects of neutrophil elastase and other proteases on porcine aortic endothelial prostaglandin I2 production, adenine nucleotide release, and responses to vasoactive agents.

7. Cytolytic effect of polylysine on rabbit polymorphonuclear leukocytes.

8. Hydrogen peroxide producing lactobacilli in women with cervical neoplasia.

9. Damage to Aspergillus fumigatus and Rhizopus oryzae hyphae by oxidative and nonoxidative microbicidal products of human neutrophils in vitro.

10. Mechanisms of attachment of neutrophils to Candida albicans pseudohyphae in the absence of serum, and of subsequent damage to pseudohyphae by microbicidal processes of neutrophils in vitro.