Literature DB >> 18264106

Tractable Cre-lox system for stochastic alteration of genes in mice.

Ashleigh J Miller1, Sandra D Dudley, Jen-Lan Tsao, Darryl Shibata, R Michael Liskay.   

Abstract

We developed a cell division-activated Cre-lox system for stochastic recombination of loxP-flanked loci in mice. Cre activation by frameshift reversion is modulated by DNA mismatch-repair status and occurs in individual cells surrounded by normal tissue, mimicking spontaneous cancer-causing mutations. This system should be particularly useful for delineating pathways of neoplasia, and determining the developmental and aging consequences of specific gene alterations.

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Year:  2008        PMID： 18264106      PMCID： PMC2394730          DOI： 10.1038/nmeth.1183

Source DB:  PubMed          Journal:  Nat Methods        ISSN： 1548-7091            Impact factor:   28.547


  14 in total

Review 1.  DNA mismatch repair and genetic instability.

Authors:  B D Harfe; S Jinks-Robertson
Journal:  Annu Rev Genet       Date:  2000       Impact factor: 16.830

Review 2.  The intestinal epithelial stem cell.

Authors:  Emma Marshman; Catherine Booth; Christopher S Potten
Journal:  Bioessays       Date:  2002-01       Impact factor: 4.345

3.  Somatic activation of the K-ras oncogene causes early onset lung cancer in mice.

Authors:  L Johnson; K Mercer; D Greenbaum; R T Bronson; D Crowley; D A Tuveson; T Jacks
Journal:  Nature       Date:  2001-04-26       Impact factor: 49.962

4.  Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras.

Authors:  E L Jackson; N Willis; K Mercer; R T Bronson; D Crowley; R Montoya; T Jacks; D A Tuveson
Journal:  Genes Dev       Date:  2001-12-15       Impact factor: 11.361

5.  Can villin be used to identify malignant and undifferentiated normal digestive epithelial cells?

Authors:  S Robine; C Huet; R Moll; C Sahuquillo-Merino; E Coudrier; A Zweibaum; D Louvard
Journal:  Proc Natl Acad Sci U S A       Date:  1985-12       Impact factor: 11.205

Review 6.  Conditional mouse models of sporadic cancer.

Authors:  Jos Jonkers; Anton Berns
Journal:  Nat Rev Cancer       Date:  2002-04       Impact factor: 60.716

7.  Male mice defective in the DNA mismatch repair gene PMS2 exhibit abnormal chromosome synapsis in meiosis.

Authors:  S M Baker; C E Bronner; L Zhang; A W Plug; M Robatzek; G Warren; E A Elliott; J Yu; T Ashley; N Arnheim; R A Flavell; R M Liskay
Journal:  Cell       Date:  1995-07-28       Impact factor: 41.582

8.  Elevated levels of mutation in multiple tissues of mice deficient in the DNA mismatch repair gene Pms2.

Authors:  L Narayanan; J A Fritzell; S M Baker; R M Liskay; P M Glazer
Journal:  Proc Natl Acad Sci U S A       Date:  1997-04-01       Impact factor: 11.205

9.  Forced expression of the tumor suppressor adenomatosis polyposis coli protein induces disordered cell migration in the intestinal epithelium.

Authors:  M H Wong; M L Hermiston; A J Syder; J I Gordon
Journal:  Proc Natl Acad Sci U S A       Date:  1996-09-03       Impact factor: 11.205

10.  Pretumor progression: clonal evolution of human stem cell populations.

Authors:  Peter Calabrese; Simon Tavaré; Darryl Shibata
Journal:  Am J Pathol       Date:  2004-04       Impact factor: 4.307
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  15 in total

Review 1.  Mouse models of inherited cancer syndromes.

Authors:  Sohail Jahid; Steven Lipkin
Journal:  Hematol Oncol Clin North Am       Date:  2010-12       Impact factor: 3.722

2.  Occult progression by Apc-deficient intestinal crypts as a target for chemoprevention.

Authors:  Jared M Fischer; Arnout G Schepers; Hans Clevers; Darryl Shibata; R Michael Liskay
Journal:  Carcinogenesis       Date:  2013-08-29       Impact factor: 4.944

3.  Harnessing mismatch repair to model sporadic cancers.

Authors:  Richard Fishel; Joanna Groden
Journal:  Nat Methods       Date:  2008-03       Impact factor: 28.547

Review 4.  Pathology of rodent models of intestinal cancer: progress report and recommendations.

Authors:  Mary Kay Washington; Anne E Powell; Ruth Sullivan; John P Sundberg; Nicholas Wright; Robert J Coffey; William F Dove
Journal:  Gastroenterology       Date:  2013-02-12       Impact factor: 22.682

5.  An intact Pms2 ATPase domain is not essential for male fertility.

Authors:  Jared M Fischer; Sandra Dudley; Ashleigh J Miller; R Michael Liskay
Journal:  DNA Repair (Amst)       Date:  2015-12-29

6.  Single cell lineage tracing reveals a role for TgfβR2 in intestinal stem cell dynamics and differentiation.

Authors:  Jared M Fischer; Peter P Calabrese; Ashleigh J Miller; Nina M Muñoz; William M Grady; Darryl Shibata; R Michael Liskay
Journal:  Proc Natl Acad Sci U S A       Date:  2016-10-10       Impact factor: 11.205

7.  Generation of a transgenic mouse for colorectal cancer research with intestinal cre expression limited to the large intestine.

Authors:  Yingben Xue; Robert Johnson; Marsha Desmet; Paul W Snyder; James C Fleet
Journal:  Mol Cancer Res       Date:  2010-07-27       Impact factor: 5.852

8.  Hair cell replacement in adult mouse utricles after targeted ablation of hair cells with diphtheria toxin.

Authors:  Justin S Golub; Ling Tong; Tot B Ngyuen; Cliff R Hume; Richard D Palmiter; Edwin W Rubel; Jennifer S Stone
Journal:  J Neurosci       Date:  2012-10-24       Impact factor: 6.167

9.  Different phenotypic consequences of simultaneous versus stepwise Apc loss.

Authors:  J M Fischer; A J Miller; D Shibata; R M Liskay
Journal:  Oncogene       Date:  2011-09-05       Impact factor: 9.867

Review 10.  Direct measurements of human colon crypt stem cell niche genetic fidelity: the role of chance in non-darwinian mutation selection.

Authors:  Haeyoun Kang; Darryl Shibata
Journal:  Front Oncol       Date:  2013-10-14       Impact factor: 6.244
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