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Literature DB >> 21075289

Mouse models of inherited cancer syndromes.

Abstract

Animal models of cancer have been instrumental in understanding the progression and therapy of hereditary cancer syndromes. The ability to alter the genome of an individual mouse cell in both constitutive and inducible approaches has led to many novel insights into their human counterparts. In this review, knockout mouse models of inherited human cancer syndromes are presented and insights from the study of these models are highlighted.

Entities: CellLine Chemical Disease Gene Mutation Species

Mesh：

Year: 2010 PMID： 21075289 PMCID： PMC3011940 DOI： 10.1016/j.hoc.2010.08.011

Source DB: PubMed Journal: Hematol Oncol Clin North Am ISSN： 0889-8588 Impact factor: 3.722

144 in total

1. Cyclooxygenase 2- and prostaglandin E(2) receptor EP(2)-dependent angiogenesis in Apc(Delta716) mouse intestinal polyps.

Authors: Hiroshi Seno; Masanobu Oshima; Tomo-o Ishikawa; Hiroko Oshima; Kazuaki Takaku; Tsutomu Chiba; Shuh Narumiya; Makoto M Taketo
Journal: Cancer Res Date: 2002-01-15 Impact factor: 12.701

2. Heterozygosity for the neurofibromatosis 1 (NF1) tumor suppressor results in abnormalities in cell attachment, spreading and motility in astrocytes.

Authors: D H Gutmann; Y L Wu; N M Hedrick; Y Zhu; A Guha; L F Parada
Journal: Hum Mol Genet Date: 2001-12-15 Impact factor: 6.150

3. Targeted disruption of the murine Fanconi anemia gene, Fancg/Xrcc9.

Authors: Y Yang; Y Kuang; R Montes De Oca; T Hays; L Moreau; N Lu; B Seed; A D D'Andrea
Journal: Blood Date: 2001-12-01 Impact factor: 22.113

4. Pten regulates neuronal soma size: a mouse model of Lhermitte-Duclos disease.

Authors: C H Kwon; X Zhu; J Zhang; L L Knoop; R Tharp; R J Smeyne; C G Eberhart; P C Burger; S J Baker
Journal: Nat Genet Date: 2001-12 Impact factor: 38.330

5. Development of mammary adenocarcinomas by tissue-specific knockout of Brca2 in mice.

Authors: T Ludwig; P Fisher; V Murty; A Efstratiadis
Journal: Oncogene Date: 2001-07-05 Impact factor: 9.867

6. Inherited variants of MYH associated with somatic G:C-->T:A mutations in colorectal tumors.

Authors: Nada Al-Tassan; Nikolas H Chmiel; Julie Maynard; Nick Fleming; Alison L Livingston; Geraint T Williams; Angela K Hodges; D Rhodri Davies; Sheila S David; Julian R Sampson; Jeremy P Cheadle
Journal: Nat Genet Date: 2002-01-30 Impact factor: 38.330

7. Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis.

Authors: N E Sharpless; N Bardeesy; K H Lee; D Carrasco; D H Castrillon; A J Aguirre; E A Wu; J W Horner; R A DePinho
Journal: Nature Date: 2001-09-06 Impact factor: 49.962

8. Atm knock-in mice harboring an in-frame deletion corresponding to the human ATM 7636del9 common mutation exhibit a variant phenotype.

Authors: K Spring; S Cross; C Li; D Watters; L Ben-Senior; P Waring; F Ahangari; S L Lu; P Chen; I Misko; C Paterson; G Kay; N I Smorodinsky; Y Shiloh; M F Lavin
Journal: Cancer Res Date: 2001-06-01 Impact factor: 12.701

9. Multiple genetic changes are associated with mammary tumorigenesis in Brca1 conditional knockout mice.

Authors: S G Brodie; X Xu; W Qiao; W M Li; L Cao; C X Deng
Journal: Oncogene Date: 2001-11-08 Impact factor: 9.867

Review 10. Animal models of tumor-suppressor genes.

Authors: R Hakem; T W Mak
Journal: Annu Rev Genet Date: 2001 Impact factor: 16.830

1 in total

1. Mismatch repair gene mutations lead to lynch syndrome colorectal cancer in rhesus macaques.

Authors: Beth K Dray; Muthuswamy Raveendran; R Alan Harris; Fernando Benavides; Stanton B Gray; Carlos J Perez; Mark J McArthur; Lawrence E Williams; Wallace B Baze; Harsha Doddapaneni; Donna M Muzny; Christian R Abee; Jeffrey Rogers
Journal: Genes Cancer Date: 2018-03

1 in total