Literature DB >> 18259603

Exploring a chemical encoding strategy for combinatorial synthesis using Friedel-Crafts alkylation.

Robin H Scott1, Colin Barnes, Ulrich Gerhard, Shankar Balasubramanian.   

Abstract

The use of scandium(III) triflate and ytterbium(III) triflate-catalysed Friedel-Crafts alkylation to insert a set of hydroxymethyl pyrrole amide tags (1b-i) on to polystyrene resins under mild conditions and the encoding of a split and mix peptide library is demonstrated.

Entities:  

Year:  1999        PMID： 18259603      PMCID： PMC2231855          DOI： 10.1039/a902489a

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  5 in total

1.  The Current Status of Heterocyclic Combinatorial Libraries.

Authors:  Adel Nefzi; John M. Ostresh; Richard A. Houghten
Journal:  Chem Rev       Date:  1997-04-01       Impact factor: 60.622

2.  General method for rapid synthesis of multicomponent peptide mixtures.

Authors:  A Furka; F Sebestyén; M Asgedom; G Dibó
Journal:  Int J Pept Protein Res       Date:  1991-06

Review 3.  Encoding strategies in combinatorial chemistry.

Authors:  A W Czarnik
Journal:  Proc Natl Acad Sci U S A       Date:  1997-11-25       Impact factor: 11.205

Review 4.  Applications of combinatorial technologies to drug discovery. 1. Background and peptide combinatorial libraries.

Authors:  M A Gallop; R W Barrett; W J Dower; S P Fodor; E M Gordon
Journal:  J Med Chem       Date:  1994-04-29       Impact factor: 7.446

5.  Versatile approach to encoding combinatorial organic syntheses using chemically robust secondary amine tags.

Authors:  Z J Ni; D Maclean; C P Holmes; M M Murphy; B Ruhland; J W Jacobs; E M Gordon; M A Gallop
Journal:  J Med Chem       Date:  1996-04-12       Impact factor: 7.446
  5 in total

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