| Literature DB >> 18258215 |
Abstract
Alternative pre-mRNA splicing is a common way of gene expression regulation in metazoans. The selective use of specific exons can be modulated in response to various manipulations that alter Ca(++) signals, particularly in neurons. A number of splicing factors have also been found to be controlled by Ca(++) signals. Moreover, pre-mRNA elements have been identified that are essential and sufficient to mediate Ca(++)-regulated splicing, providing model systems for dissecting the involved molecular components. In neurons, this regulation likely contributes to the fine-tuning of neuronal properties.Mesh：
Substances：
Year: 2008 PMID： 18258215 PMCID： PMC3500379 DOI： 10.1016/j.bbagrm.2008.01.003
Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002