| Literature DB >> 18255289 |
T Hari Babu1, V Rama Subba Rao, Ashok K Tiwari, K Suresh Babu, P V Srinivas, Amtul Z Ali, J Madhusudana Rao.
Abstract
A series of 8-aminomethylated derivatives (1a-1j) were prepared by Mannich reaction of oroxylin A (1) with appropriate primary or secondary amines and para-formaldehyde. All the compounds were tested for their alpha-glucosidase inhibition activity against both yeast and rat intestinal alpha-glucosidase. Some of the compounds demonstrated significantly better alpha-glucosidase inhibitory activity than the parent compound (oroxylin A).Entities:
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Year: 2008 PMID： 18255289 DOI： 10.1016/j.bmcl.2008.01.055
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823