| Literature DB >> 18254637 |
Mohammed Abid1, Liliana Teixeira, Béla Török.
Abstract
A simple and efficient synthesis to both enantiomers of highly enantiomerically enriched alpha-trifluoromethyl-alpha-(heteroaryl)-glycine derivatives via highly stereoselective aminoalkylation of indoles and pyrroles is described. The triflic acid-catalyzed reaction of enantiomeric 3,3,3-trifluoro-pyruvate-alpha-methylbenzyl imines with indoles and pyrroles and the subsequent Pd-catalyzed hydrogenolysis of the methylbenzyl group provided the products in high yields and excellent enantioselectivities.Entities:
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Year: 2008 PMID： 18254637 DOI： 10.1021/ol703095d
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005