| Literature DB >> 18254600 |
Erik Fenster1, Dinesh K Rayabarapu, Mianji Zhang, Shubhasish Mukherjee, David Hill, Ben Neuenswander, Frank Schoenen, Paul R Hanson, Jeffrey Aubé.
Abstract
The parallel synthesis of gamma-turn-inspired peptidomimetic libraries has been demonstrated through two approaches toward the preparation of 1,4-diazepin-5-ones. In the first approach, 1,4-diazepin-5-ones scaffolds were prepared on gram scale and subsequently diversified to produce libraries. In a second approach, libraries of 1,4-diazepin-5-ones were produced directly through a three-component strategy that maximizes the diversity obtained in a single step.Entities:
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Year: 2008 PMID： 18254600 DOI： 10.1021/cc700174c
Source DB: PubMed Journal: J Comb Chem ISSN： 1520-4766