| Literature DB >> 18253139 |
Kenneth J Chang1, John G Lee, Randall F Holcombe, Jeffrey Kuo, Raman Muthusamy, Mark L Wu.
Abstract
BACKGROUND: A 72-year-old white male presented to a University Digestive Disease Center with epigastric pain and weight loss. A CT scan suggested that the patient had a mass in his pancreas and he was referred for further diagnostic work-up, staging and treatment. INVESTIGATIONS: Endoscopic ultrasound (EUS), EUS-guided fine-needle aspiration. DIAGNOSIS: Locally advanced, unresectable adenocarcinoma of the pancreas. MANAGEMENT: Opioid analgesics and EUS-guided celiac neurolysis (transgastric injection of bupivacaine and alcohol on both sides of the celiac artery) for pain relief. Five once-weekly intratumoral injections of TNFerade (GenVec, Inc., Gaithersburg, MD) by EUS-guided fine needle injection, in combination with chemoradiation (5 FU/XRT), as part of a multicenter clinical trial. Repeat fine-needle aspiration followed by surgical resection of the tumor.Entities:
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Year: 2008 PMID： 18253139 DOI： 10.1038/ncpgasthep1033
Source DB: PubMed Journal: Nat Clin Pract Gastroenterol Hepatol ISSN： 1743-4378