| Literature DB >> 18251675 |
Peter M Visscher1, Scott Gordon, Michael C Neale.
Abstract
We expand our previous deterministic power calculations by calculating the required sample size to detect C in ACE models. The theoretical expected value of the maximum log-likelihood for the AE model was derived using two optimisation methods and these gave near-identical results. Theoretical predictions were verified by computer simulation and the results agreed very well. We have developed a user-friendly web-based tool, TwinPower, to perform power calculations to detect either A or C for the classical twin design. This new tool can be found at http://genepi.qimr.edu.au/cgi-bin/twinpower.cgi.Entities:
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Year: 2008 PMID: 18251675 PMCID: PMC3996914 DOI: 10.1375/twin.11.1.48
Source DB: PubMed Journal: Twin Res Hum Genet ISSN: 1832-4274 Impact factor: 1.587