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Literature DB >> 18250311

Evolution of polyketide synthases in bacteria.

Christian P Ridley¹, Ho Young Lee, Chaitan Khosla.

Abstract

The emergence of resistant strains of human pathogens to current antibiotics, along with the demonstrated ability of polyketides as antimicrobial agents, provides strong motivation for understanding how polyketide antibiotics have evolved and diversified in nature. Insights into how bacterial polyketide synthases (PKSs) acquire new metabolic capabilities can guide future laboratory efforts in generating the next generation of polyketide antibiotics. Here, we examine phylogenetic and structural evidence to glean answers to two general questions regarding PKS evolution. How did the exceptionally diverse chemistry of present-day PKSs evolve? And what are the take-home messages for the biosynthetic engineer?

Entities: Chemical Species

Mesh：

Substances：

Year: 2008 PMID： 18250311 PMCID： PMC2290765 DOI： 10.1073/pnas.0710107105

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

49 in total

Review 1. Type II polyketide synthases: gaining a deeper insight into enzymatic teamwork.

Authors: Christian Hertweck; Andriy Luzhetskyy; Yuri Rebets; Andreas Bechthold
Journal: Nat Prod Rep Date: 2006-11-22 Impact factor: 13.423

2. Identification of the putative bryostatin polyketide synthase gene cluster from "Candidatus Endobugula sertula", the uncultivated microbial symbiont of the marine bryozoan Bugula neritina.

Authors: Sebastian Sudek; Nicole B Lopanik; Laura E Waggoner; Mark Hildebrand; Christine Anderson; Haibin Liu; Amrish Patel; David H Sherman; Margo G Haygood
Journal: J Nat Prod Date: 2007-01 Impact factor: 4.050

3. The biosynthetic genes for disorazoles, potent cytotoxic compounds that disrupt microtubule formation.

Authors: Ruby Carvalho; Ralph Reid; Nina Viswanathan; Hugo Gramajo; Bryan Julien
Journal: Gene Date: 2005-10-10 Impact factor: 3.688

4. Characterization of the biosynthetic gene cluster for the antifungal polyketide soraphen A from Sorangium cellulosum So ce26.

Authors: James Ligon; Steven Hill; James Beck; Ross Zirkle; István Molnár; Jennifer Zawodny; Stephanie Money; Thomas Schupp
Journal: Gene Date: 2002-02-20 Impact factor: 3.688

5. A polyketide synthase-peptide synthetase gene cluster from an uncultured bacterial symbiont of Paederus beetles.

Authors: Jörn Piel
Journal: Proc Natl Acad Sci U S A Date: 2002-10-14 Impact factor: 11.205

6. The Streptomyces peucetius dpsC gene determines the choice of starter unit in biosynthesis of the daunorubicin polyketide.

Authors: W Bao; P J Sheldon; E Wendt-Pienkowski; C R Hutchinson
Journal: J Bacteriol Date: 1999-08 Impact factor: 3.490

7. Priming type II polyketide synthases via a type II nonribosomal peptide synthetase mechanism.

Authors: Miho Izumikawa; Qian Cheng; Bradley S Moore
Journal: J Am Chem Soc Date: 2006-02-08 Impact factor: 15.419

8. Biosynthesis of the antitumor agent chartreusin involves the oxidative rearrangement of an anthracyclic polyketide.

Authors: Zhongli Xu; Kathrin Jakobi; Katrin Welzel; Christian Hertweck
Journal: Chem Biol Date: 2005-05

9. The FK520 gene cluster of Streptomyces hygroscopicus var. ascomyceticus (ATCC 14891) contains genes for biosynthesis of unusual polyketide extender units.

Authors: K Wu; L Chung; W P Revill; L Katz; C D Reeves
Journal: Gene Date: 2000-06-13 Impact factor: 3.688

10. Polyketide chain length control by chain length factor.

Authors: Yi Tang; Shiou-Chuan Tsai; Chaitan Khosla
Journal: J Am Chem Soc Date: 2003-10-22 Impact factor: 15.419

67 in total

1. Horizontal gene transfer and gene conversion drive evolution of modular polyketide synthases.

Authors: Jurica Zucko; Paul F Long; Daslav Hranueli; John Cullum
Journal: J Ind Microbiol Biotechnol Date: 2012-05-30 Impact factor: 3.346

2. The discovery of salinosporamide K from the marine bacterium "Salinispora pacifica" by genome mining gives insight into pathway evolution.

Authors: Alessandra S Eustáquio; Sang-Jip Nam; Kevin Penn; Anna Lechner; Micheal C Wilson; William Fenical; Paul R Jensen; Bradley S Moore
Journal: Chembiochem Date: 2011-01-03 Impact factor: 3.164

Review 3. Health Effects of Toxic Cyanobacteria in U.S. Drinking and Recreational Waters: Our Current Understanding and Proposed Direction.

Authors: Timothy G Otten; Hans W Paerl
Journal: Curr Environ Health Rep Date: 2015-03

Evolution of polyketide synthases in bacteria.

Review 1. Type II polyketide synthases: gaining a deeper insight into enzymatic teamwork.

2. Identification of the putative bryostatin polyketide synthase gene cluster from "Candidatus Endobugula sertula", the uncultivated microbial symbiont of the marine bryozoan Bugula neritina.

3. The biosynthetic genes for disorazoles, potent cytotoxic compounds that disrupt microtubule formation.

4. Characterization of the biosynthetic gene cluster for the antifungal polyketide soraphen A from Sorangium cellulosum So ce26.

5. A polyketide synthase-peptide synthetase gene cluster from an uncultured bacterial symbiont of Paederus beetles.

6. The Streptomyces peucetius dpsC gene determines the choice of starter unit in biosynthesis of the daunorubicin polyketide.

7. Priming type II polyketide synthases via a type II nonribosomal peptide synthetase mechanism.

8. Biosynthesis of the antitumor agent chartreusin involves the oxidative rearrangement of an anthracyclic polyketide.

9. The FK520 gene cluster of Streptomyces hygroscopicus var. ascomyceticus (ATCC 14891) contains genes for biosynthesis of unusual polyketide extender units.

10. Polyketide chain length control by chain length factor.

1. Horizontal gene transfer and gene conversion drive evolution of modular polyketide synthases.

2. The discovery of salinosporamide K from the marine bacterium "Salinispora pacifica" by genome mining gives insight into pathway evolution.

Review 3. Health Effects of Toxic Cyanobacteria in U.S. Drinking and Recreational Waters: Our Current Understanding and Proposed Direction.

4. Evolution of chemical diversity by coordinated gene swaps in type II polyketide gene clusters.

5. Chemical ecology in retrospect and prospect.

Review 6. Engineering the acyltransferase substrate specificity of assembly line polyketide synthases.

Review 7. Evolutionary concepts in natural products discovery: what actinomycetes have taught us.

Review 8. Bioinformatics tools for genome mining of polyketide and non-ribosomal peptides.

9. Molecular insights into the biosynthesis of guadinomine: a type III secretion system inhibitor.

Review 10. Biosynthesis of aromatic polyketides in bacteria.