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Literature DB >> 17268612

Type II polyketide synthases: gaining a deeper insight into enzymatic teamwork.

Christian Hertweck¹, Andriy Luzhetskyy, Yuri Rebets, Andreas Bechthold.

Abstract

This review covers advances in understanding of the biosynthesis of polyketides produced by type II PKS systems at the genetic, biochemical and structural levels.

Entities: Chemical

Mesh：

Substances：

Year: 2006 PMID： 17268612 DOI： 10.1039/b507395m

Source DB: PubMed Journal: Nat Prod Rep ISSN： 0265-0568 Impact factor: 13.423

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Cited

126 in total

1. A biosynthetic pathway for BE-7585A, a 2-thiosugar-containing angucycline-type natural product.

Authors: Eita Sasaki; Yasushi Ogasawara; Hung-Wen Liu
Journal: J Am Chem Soc Date: 2010-06-02 Impact factor: 15.419

Review 2. New insights into the formation of fungal aromatic polyketides.

Authors: Jason M Crawford; Craig A Townsend
Journal: Nat Rev Microbiol Date: 2010-12 Impact factor: 60.633

3. Evolution of chemical diversity by coordinated gene swaps in type II polyketide gene clusters.

Authors: Maureen E Hillenmeyer; Gergana A Vandova; Erin E Berlew; Louise K Charkoudian
Journal: Proc Natl Acad Sci U S A Date: 2015-10-23 Impact factor: 11.205

Review 4. Protein engineering towards natural product synthesis and diversification.

Authors: Angelica O Zabala; Ralph A Cacho; Yi Tang
Journal: J Ind Microbiol Biotechnol Date: 2011-10-18 Impact factor: 3.346

5. Formation of an Angular Aromatic Polyketide from a Linear Anthrene Precursor via Oxidative Rearrangement.

Authors: Guixi Gao; Xiangyang Liu; Min Xu; Yemin Wang; Fei Zhang; Lijun Xu; Jin Lv; Qingshan Long; Qianjin Kang; Hong-Yu Ou; Ying Wang; Jürgen Rohr; Zixin Deng; Ming Jiang; Shuangjun Lin; Meifeng Tao
Journal: Cell Chem Biol Date: 2017-07-14 Impact factor: 8.116

Type II polyketide synthases: gaining a deeper insight into enzymatic teamwork.

1. A biosynthetic pathway for BE-7585A, a 2-thiosugar-containing angucycline-type natural product.

Review 2. New insights into the formation of fungal aromatic polyketides.

3. Evolution of chemical diversity by coordinated gene swaps in type II polyketide gene clusters.

Review 4. Protein engineering towards natural product synthesis and diversification.

5. Formation of an Angular Aromatic Polyketide from a Linear Anthrene Precursor via Oxidative Rearrangement.

Review 6. Total (bio)synthesis: strategies of nature and of chemists.

7. Engineered biosynthesis of bacterial aromatic polyketides in Escherichia coli.

Review 8. Biosynthesis of aromatic polyketides in bacteria.

9. Probing the compatibility of type II ketosynthase-carrier protein partners.

10. Biochemical analysis of the biosynthetic pathway of an anticancer tetracycline SF2575.