Literature DB >> 18249108

Polo and Aurora kinases: lessons derived from chemical biology.

Stephen Taylor1, Jan-Michael Peters.   

Abstract

During the cell division cycle, mitotic entry, spindle assembly, chromosome segregation, and cytokinesis must all be carefully coordinated to ensure that the two daughter cells inherit all the genetic material required for further growth and development. Central to this coordination are several protein kinases including Aurora A, Aurora B, and the Polo-like kinase, Plk1. A number of small-molecule Aurora and Plk1 inhibitors have been developed because these kinases are seen as attractive anticancer drug targets. These inhibitors are now being widely used as chemical biology tools to understand how these kinases ensure faithful genome transmission.

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Year:  2008        PMID： 18249108     DOI： 10.1016/j.ceb.2007.11.008

Source DB:  PubMed          Journal:  Curr Opin Cell Biol        ISSN： 0955-0674            Impact factor:   8.382


  62 in total

1.  Polo-like kinase 1 regulates cell proliferation and is targeted by miR-593* in esophageal cancer.

Authors:  Tetsuo Ito; Fumiaki Sato; Takatsugu Kan; Yulan Cheng; Stefan David; Rachana Agarwal; Bogdan C Paun; Zhe Jin; Alexandru V Olaru; James P Hamilton; Florin M Selaru; Jian Yang; Nobutoshi Matsumura; Kazuharu Shimizu; John M Abraham; Yutaka Shimada; Yuriko Mori; Stephen J Meltzer
Journal:  Int J Cancer       Date:  2011-03-11       Impact factor: 7.396

Review 2.  APC/C-Cdh1: from cell cycle to cellular differentiation and genomic integrity.

Authors:  Xinxian Qiao; Liyong Zhang; Armin M Gamper; Takeo Fujita; Yong Wan
Journal:  Cell Cycle       Date:  2010-10-11       Impact factor: 4.534

Review 3.  Mitosis is not a key target of microtubule agents in patient tumors.

Authors:  Edina Komlodi-Pasztor; Dan Sackett; Julia Wilkerson; Tito Fojo
Journal:  Nat Rev Clin Oncol       Date:  2011-02-01       Impact factor: 66.675

4.  Tankyrase-1 function at telomeres and during mitosis is regulated by Polo-like kinase-1-mediated phosphorylation.

Authors:  G-H Ha; H-S Kim; H Go; H Lee; H Seimiya; D H Chung; C-W Lee
Journal:  Cell Death Differ       Date:  2011-08-05       Impact factor: 15.828

5.  Regulation of cortical contractility and spindle positioning by the protein phosphatase 6 PPH-6 in one-cell stage C. elegans embryos.

Authors:  Katayoun Afshar; Michael E Werner; Yu Chung Tse; Michael Glotzer; Pierre Gönczy
Journal:  Development       Date:  2010-01       Impact factor: 6.868

6.  Quantitative proteomic analysis of purified yeast kinetochores identifies a PP1 regulatory subunit.

Authors:  Bungo Akiyoshi; Christian R Nelson; Jeffrey A Ranish; Sue Biggins
Journal:  Genes Dev       Date:  2009-12-15       Impact factor: 11.361

Review 7.  Cell cycle, CDKs and cancer: a changing paradigm.

Authors:  Marcos Malumbres; Mariano Barbacid
Journal:  Nat Rev Cancer       Date:  2009-03       Impact factor: 60.716

8.  Cyclin-dependent kinase 4 signaling acts as a molecular switch between syngenic differentiation and neural transdifferentiation in human mesenchymal stem cells.

Authors:  Janet Lee; Jeong-Hwa Baek; Kyu-Sil Choi; Hyun-Soo Kim; Hye-Young Park; Geun-Hyoung Ha; Ho Park; Kyo-Won Lee; Chang Geun Lee; Dong-Yun Yang; Hyo Eun Moon; Sun Ha Paek; Chang-Woo Lee
Journal:  Cell Cycle       Date:  2013-01-16       Impact factor: 4.534

9.  Regulation of polo-like kinase 1 by DNA damage and PP2A/B55α.

Authors:  Ling Wang; Qingyuan Guo; Laura A Fisher; Dongxu Liu; Aimin Peng
Journal:  Cell Cycle       Date:  2015       Impact factor: 4.534

10.  Binding partner switching on microtubules and aurora-B in the mitosis to cytokinesis transition.

Authors:  Nurhan Ozlü; Flavio Monigatti; Bernhard Y Renard; Christine M Field; Hanno Steen; Timothy J Mitchison; Judith J Steen
Journal:  Mol Cell Proteomics       Date:  2009-09-28       Impact factor: 5.911
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