Literature DB >> 18246075

A systematic library for comprehensive overexpression screens in Saccharomyces cerevisiae.

Grace Marie Jones1, Jim Stalker, Sean Humphray, Anthony West, Tony Cox, Jane Rogers, Ian Dunham, Gregory Prelich.   

Abstract

Modern genetic analysis requires the development of new resources to systematically explore gene function in vivo. Overexpression screens are a powerful method to investigate genetic pathways, but the goal of routine and comprehensive overexpression screens has been hampered by the lack of systematic libraries. Here we describe the construction of a systematic collection of the Saccharomyces cerevisiae genome in a high-copy vector and its validation in two overexpression screens.

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Year:  2008        PMID： 18246075     DOI： 10.1038/nmeth.1181

Source DB:  PubMed          Journal:  Nat Methods        ISSN： 1548-7091            Impact factor:   28.547


  102 in total

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