RATIONALE: The basis for gender influences on allergen-specific IgEs is unclear. OBJECTIVES: To perform regular and sex-stratified genomewide linkage analyses of IgE to each of three allergens (Ascaris lumbricoides, Blatella germanica [German cockroach]), and Dermatophagoides pteronyssinus [dust mite]) and to conduct an association study of a candidate gene in a linked genomic region. METHODS: Genomewide linkage analyses of allergen-specific IgEs were conducted in 653 members of eight large families of Costa Rican children with asthma. An analysis of the association between single-nucleotide polymorphisms in thymic stromal lymphopoietin (TSLP) and IgE measurements was conducted in 417 parent-child trios in Costa Rica. Significant results were replicated in 470 families of white children in the Childhood Asthma Management Program (CAMP). MEASUREMENTS AND MAIN RESULTS: Among all subjects, there was suggestive evidence of linkage (LOD >/= 2.72) to IgE to Ascaris (on chromosome 7q) and IgE to dust mite (on chromosomes 7p and 12q). In a sex-stratified analysis, there was significant evidence of linkage to IgE to cockroach on chromosome 5q23 (peak LOD, 4.14 at 127 cM) in female subjects. TSLP is located within the 1.5 LOD-unit support interval for this linkage peak and has female-specific effects on lung disease in mice. In a sex-stratified analysis, the T allele of single-nucleotide polymorphism rs2289276 in TSLP was associated with reductions in IgE to cockroach (in Costa Rican girls) and total IgE (in girls in Costa Rica and in CAMP; P value for sex-by-genotype interaction, <0.01 in both studies). CONCLUSIONS: Consistent with findings in murine models, a variant in TSLP may have female-specific effects on allergic phenotypes.
RATIONALE: The basis for gender influences on allergen-specific IgEs is unclear. OBJECTIVES: To perform regular and sex-stratified genomewide linkage analyses of IgE to each of three allergens (Ascaris lumbricoides, Blatella germanica [German cockroach]), and Dermatophagoides pteronyssinus [dust mite]) and to conduct an association study of a candidate gene in a linked genomic region. METHODS: Genomewide linkage analyses of allergen-specific IgEs were conducted in 653 members of eight large families of Costa Rican children with asthma. An analysis of the association between single-nucleotide polymorphisms in thymic stromal lymphopoietin (TSLP) and IgE measurements was conducted in 417 parent-child trios in Costa Rica. Significant results were replicated in 470 families of white children in the Childhood Asthma Management Program (CAMP). MEASUREMENTS AND MAIN RESULTS: Among all subjects, there was suggestive evidence of linkage (LOD >/= 2.72) to IgE to Ascaris (on chromosome 7q) and IgE to dust mite (on chromosomes 7p and 12q). In a sex-stratified analysis, there was significant evidence of linkage to IgE to cockroach on chromosome 5q23 (peak LOD, 4.14 at 127 cM) in female subjects. TSLP is located within the 1.5 LOD-unit support interval for this linkage peak and has female-specific effects on lung disease in mice. In a sex-stratified analysis, the T allele of single-nucleotide polymorphism rs2289276 in TSLP was associated with reductions in IgE to cockroach (in Costa Rican girls) and total IgE (in girls in Costa Rica and in CAMP; P value for sex-by-genotype interaction, <0.01 in both studies). CONCLUSIONS: Consistent with findings in murine models, a variant in TSLP may have female-specific effects on allergic phenotypes.
Authors: D L Rosenstreich; P Eggleston; M Kattan; D Baker; R G Slavin; P Gergen; H Mitchell; K McNiff-Mortimer; H Lynn; D Ownby; F Malveaux Journal: N Engl J Med Date: 1997-05-08 Impact factor: 91.245
Authors: M A Escamilla; M Spesny; V I Reus; A Gallegos; L Meza; J Molina; L A Sandkuijl; E Fournier; P E Leon; L B Smith; N B Freimer Journal: Am J Med Genet Date: 1996-05-31
Authors: M N Blumenthal; C Ober; T H Beaty; E R Bleecker; C D Langefeld; R A King; L Lester; N Cox; K Barnes; A Togias; R Mathias; D A Meyers; W Oetting; S S Rich Journal: Genes Immun Date: 2004-05 Impact factor: 2.676
Authors: Amy Murphy; Kelan G Tantisira; Manuel E Soto-Quirós; Lydiana Avila; Barbara J Klanderman; Stephen Lake; Scott T Weiss; Juan C Celedón Journal: Am J Hum Genet Date: 2009-07-02 Impact factor: 11.025
Authors: N Acevedo; D Mercado; C Vergara; J Sánchez; M W Kennedy; S Jiménez; A M Fernández; M Gutiérrez; L Puerta; L Caraballo Journal: Clin Exp Immunol Date: 2009-08 Impact factor: 4.330
Authors: Rajesh Kumar; Elizabeth A Nguyen; Lindsey A Roth; Sam S Oh; Christopher R Gignoux; Scott Huntsman; Celeste Eng; Andres Moreno-Estrada; Karla Sandoval; Rosenda I Peñaloza-Espinosa; Marisol López-López; Pedro C Avila; Harold J Farber; Haig Tcheurekdjian; William Rodriguez-Cintron; Jose R Rodriguez-Santana; Denise Serebrisky; Shannon M Thyne; L Keoki Williams; Cheryl Winkler; Carlos D Bustamante; Eliseo J Pérez-Stable; Luisa N Borrell; Esteban G Burchard Journal: J Allergy Clin Immunol Date: 2013-05-16 Impact factor: 10.793
Authors: Max A Seibold; Bin Wang; Celeste Eng; Gunjan Kumar; Kenneth B Beckman; Saunak Sen; Shweta Choudhry; Kelley Meade; Michael Lenoir; H Geoffrey Watson; Shannon Thyne; L Keoki Williams; Rajesh Kumar; Kevin B Weiss; Leslie C Grammer; Pedro C Avila; Robert P Schleimer; Esteban González Burchard; Robert Brenner Journal: Hum Mol Genet Date: 2008-06-04 Impact factor: 6.150