BACKGROUND: Allergic sensitization is increased among offspring of sensitized parents. OBJECTIVE: We sought to evaluate whether 18-year-old offspring are likely to have the same allergic sensitizations as their parents. METHODS: Eighteen-year-old participants in an unselected birth cohort and their parents were tested for total and increased (>0.35 kU/L) levels of allergen-specific IgE to 6 allergens: Dermatophagoides farinae, dog, cat, grass, ragweed, and Alternaria alternata. RESULTS: In 316 parent-teen triads parental sensitization to any of 6 allergens was associated with teen sensitization to any of those same allergens. An increased risk of matched sensitization (ie, a teen has an increased risk of being sensitized to the same specific allergen as their parent) was found after adjusting for the spouse's sensitivities and adjusting for other allergens (ie, the parent had an allergic sensitization but not to the particular allergen under analysis). Risk of maternal matched sensitization with their teen to cat (adjusted odds ratio [aOR], 2.1; 95% CI, 1.0-4.5), grass (aOR, 2.5; 95% CI, 1.2-5.2), and A alternata (aOR, 2.4; 95% CI, 1.1-5.5) was increased when compared with that seen in teens without parental allergen-specific sensitization. Similarly, a higher than expected risk of paternal matched sensitization with their teen to dog (aOR, 2.7; 95% CI, 1.3-5.9), D farinae (aOR, 2.7; 95% CI, 1.4-5.1), and grass (aOR, 2.7; 95% CI, 1.5-5.9) was observed. CONCLUSION: Parental allergen-specific IgE increases the likelihood of sensitization to the same allergen in young adult offspring.
BACKGROUND:Allergic sensitization is increased among offspring of sensitized parents. OBJECTIVE: We sought to evaluate whether 18-year-old offspring are likely to have the same allergic sensitizations as their parents. METHODS: Eighteen-year-old participants in an unselected birth cohort and their parents were tested for total and increased (>0.35 kU/L) levels of allergen-specific IgE to 6 allergens: Dermatophagoides farinae, dog, cat, grass, ragweed, and Alternaria alternata. RESULTS: In 316 parent-teen triads parental sensitization to any of 6 allergens was associated with teen sensitization to any of those same allergens. An increased risk of matched sensitization (ie, a teen has an increased risk of being sensitized to the same specific allergen as their parent) was found after adjusting for the spouse's sensitivities and adjusting for other allergens (ie, the parent had an allergic sensitization but not to the particular allergen under analysis). Risk of maternal matched sensitization with their teen to cat (adjusted odds ratio [aOR], 2.1; 95% CI, 1.0-4.5), grass (aOR, 2.5; 95% CI, 1.2-5.2), and A alternata (aOR, 2.4; 95% CI, 1.1-5.5) was increased when compared with that seen in teens without parental allergen-specific sensitization. Similarly, a higher than expected risk of paternal matched sensitization with their teen to dog (aOR, 2.7; 95% CI, 1.3-5.9), D farinae (aOR, 2.7; 95% CI, 1.4-5.1), and grass (aOR, 2.7; 95% CI, 1.5-5.9) was observed. CONCLUSION: Parental allergen-specific IgE increases the likelihood of sensitization to the same allergen in young adult offspring.
Authors: W O Cookson; R P Young; A J Sandford; M F Moffatt; T Shirakawa; P A Sharp; J A Faux; C Julier; Y Nakumuura; Y Nakumura Journal: Lancet Date: 1992-08-15 Impact factor: 79.321
Authors: Sharon Hensley Alford; Edward Zoratti; Edward L Peterson; Mary Maliarik; Dennis R Ownby; Christine Cole Johnson Journal: J Allergy Clin Immunol Date: 2004-11 Impact factor: 10.793
Authors: D G Marsh; S H Hsu; M Roebber; E Ehrlich-Kautzky; L R Freidhoff; D A Meyers; M K Pollard; W B Bias Journal: J Exp Med Date: 1982-05-01 Impact factor: 14.307
Authors: Chathruckan Rajendra; Edward Zoratti; Suzanne Havstad; Charlotte Nicholas; Ganesa Wegienka; M Todd Cross; Christine C Johnson; Dennis Ownby Journal: Ann Allergy Asthma Immunol Date: 2012-06 Impact factor: 6.347
Authors: Karthik R Krishnan; Edward L Peterson; Ganesa Wegienka; Suzanne Havstad; Christine Cole Johnson; Edward M Zoratti; Dennis R Ownby Journal: Ann Allergy Asthma Immunol Date: 2010-11 Impact factor: 6.347