| Literature DB >> 18242992 |
Carl R Illig1, Jinsheng Chen, Mark J Wall, Kenneth J Wilson, Shelley K Ballentine, M Jonathan Rudolph, Renee L DesJarlais, Yanmin Chen, Carsten Schubert, Ioanna Petrounia, Carl S Crysler, Christopher J Molloy, Margery A Chaikin, Carl L Manthey, Mark R Player, Bruce E Tomczuk, Sanath K Meegalla.
Abstract
The optimization of the arylamide lead 2 resulted in identification of a highly potent series of 2,4-disubstituted arylamides. Compound 8 (FMS kinase IC(50)=0.0008 microM) served as a proof-of-concept candidate in a collagen-induced model of arthritis in mice.Entities:
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Year: 2008 PMID： 18242992 DOI： 10.1016/j.bmcl.2008.01.059
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823