| Literature DB >> 18242784 |
Ravindra K Rawal1, Rajkamal Tripathi, S B Katti, Christophe Pannecouque, Erik De Clercq.
Abstract
A series of 2-(2,6-dibromophenyl)-3-heteroaryl-1,3-thiazolidin-4-ones were designed, synthesized and evaluated as selective human immunodeficiency virus type-1 reverse transcriptase (HIV-1 RT) enzyme inhibitors. The results of the HIV-1 RT kit and in vitro cell based assay showed that eight compounds effectively inhibited HIV-1 replication at 20-320 nM concentrations with minimal cytotoxicity in MT-4 as well as in CEM cells.Entities:
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Year: 2007 PMID： 18242784 DOI： 10.1016/j.ejmech.2007.12.015
Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514