| Literature DB >> 18242514 |
Hosein Kouros-Mehr1, Seth K Bechis, Euan M Slorach, Laurie E Littlepage, Mikala Egeblad, Andrew J Ewald, Sung-Yun Pai, I-Cheng Ho, Zena Werb.
Abstract
How breast cancers are able to disseminate and metastasize is poorly understood. Using a hyperplasia transplant system, we show that tumor dissemination and metastasis occur in discrete steps during tumor progression. Bioinformatic analysis revealed that loss of the transcription factor GATA-3 marked progression from adenoma to early carcinoma and onset of tumor dissemination. Restoration of GATA-3 in late carcinomas induced tumor differentiation and suppressed tumor dissemination. Targeted deletion of GATA-3 in early tumors led to apoptosis of differentiated cells, indicating that its loss is not sufficient for malignant conversion. Rather, malignant progression occurred with an expanding GATA-3-negative tumor cell population. These data indicate that GATA-3 regulates tumor differentiation and suppresses tumor dissemination in breast cancer.Entities:
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Year: 2008 PMID： 18242514 PMCID： PMC2262951 DOI： 10.1016/j.ccr.2008.01.011
Source DB: PubMed Journal: Cancer Cell ISSN： 1535-6108 Impact factor: 31.743