| Literature DB >> 18242175 |
Yariv Kanfi1, Ronnie Shalman, Victoria Peshti, Shmuel N Pilosof, Yosi M Gozlan, Kevin J Pearson, Batya Lerrer, Danesh Moazed, Jean-Christophe Marine, Rafael de Cabo, Haim Y Cohen.
Abstract
Sirtuins have been shown to regulate life-span in response to nutritional availability. We show here that levels of the mammalian sirtuin, SIRT6, increased upon nutrient deprivation in cultured cells, in mice after fasting, and in rats fed a calorie-restricted diet. The increase in SIRT6 levels is due to stabilization of SIRT6 protein, and not via an increase in SIRT6 transcription. In addition, p53 positively regulates SIRT6 protein levels under standard growth conditions but has no role in the nutrient-dependent regulation of SIRT6. These observations imply that at least two sirtuins are involved in regulation of life-span by nutrient availability.Entities:
Mesh：
Substances：
Year: 2008 PMID： 18242175 PMCID： PMC3263697 DOI： 10.1016/j.febslet.2008.01.019
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124