Intervening attenuation affects first-order statistical properties of ultrasound echo signals.

Previous studies show that first-order statistical properties of ultrasound echo signals are related to the effective number of scatterers in the "resolution cell" of a pulse-echo ultrasound system. When the effective number of scatterers is large (~10 or more) this results in echo signals whose amplitude follows a Rayleigh distribution, with the RF echo signal obeying Gaussian statistics; deviation from Rayleigh or Gaussian statistics yields information on scatterer number densities. In this paper, the influence of the medium's attenuation on non-Gaussian properties of the echo signal is considered. Preferential attenuation of higher frequency components of a pulsed ultrasound beam effectively broadens the beam and increases the resolution cell size. Thus, the resultant non-Gaussian parameter for broad bandwidth excitation of the transducer depends not only on the scatterer number density but also on the attenuation in the medium. These effects can be reduced or eliminated by using narrow-band experiments.