BACKGROUND AND PURPOSE: To investigate factors associated with radiation-induced nausea and vomiting (RINV) in the setting of head and neck intensity modulated radiation therapy (IMRT). MATERIALS AND METHODS: Forty-three patients treated with IMRT for head and neck cancer between 2002 and 2007 comprise the cohort. The majority (79%) were treated with an accelerated altered fractionation scheme, and concurrent chemotherapy was delivered to 23. A retrospective review of factors associated with nausea was performed. RESULTS: Eighteen patients (42%) reported grade 1 acute nausea, and seven patients (16%) reported grade 2 nausea. Factors significant for grade 1-2 nausea on univariate analysis included dose to the dorsal vagal complex of the mid-medulla, younger age, use of a low neck field, and Amifostine use. Only young age retained significance on multivariate analysis. High-grade nausea was associated with use of Amifostine (p=0.003) and concurrent chemotherapy (p=0.015). CONCLUSIONS: In addition to previously recognized emetic factors, young age and radiation dose to the dorsal vagal complex of the brainstem may play a role in development of nausea during head and neck IMRT.
BACKGROUND AND PURPOSE: To investigate factors associated with radiation-induced nausea and vomiting (RINV) in the setting of head and neck intensity modulated radiation therapy (IMRT). MATERIALS AND METHODS: Forty-three patients treated with IMRT for head and neck cancer between 2002 and 2007 comprise the cohort. The majority (79%) were treated with an accelerated altered fractionation scheme, and concurrent chemotherapy was delivered to 23. A retrospective review of factors associated with nausea was performed. RESULTS: Eighteen patients (42%) reported grade 1 acute nausea, and seven patients (16%) reported grade 2 nausea. Factors significant for grade 1-2 nausea on univariate analysis included dose to the dorsal vagal complex of the mid-medulla, younger age, use of a low neck field, and Amifostine use. Only young age retained significance on multivariate analysis. High-grade nausea was associated with use of Amifostine (p=0.003) and concurrent chemotherapy (p=0.015). CONCLUSIONS: In addition to previously recognized emetic factors, young age and radiation dose to the dorsal vagal complex of the brainstem may play a role in development of nausea during head and neck IMRT.
Authors: Jason M York; Neil A Blevins; Daryl D Meling; Molly B Peterlin; Daila S Gridley; Keith A Cengel; Gregory G Freund Journal: Brain Behav Immun Date: 2011-09-21 Impact factor: 7.217
Authors: Kihoon Nam; Christina L Maruyama; Bryan G Trump; Luke Buchmann; Jason P Hunt; Marcus M Monroe; Olga J Baker Journal: J Histochem Cytochem Date: 2016-04-28 Impact factor: 2.479
Authors: Esengul Kocak-Uzel; G Brandon Gunn; Rivka R Colen; Micheal E Kantor; Abdallah S R Mohamed; Sara Schoultz-Henley; Paniyotis Mavroidis; Steven J Frank; Adam S Garden; Beth M Beadle; William H Morrison; Jack Phan; David I Rosenthal; Clifton D Fuller Journal: Radiother Oncol Date: 2014-04-17 Impact factor: 6.280
Authors: Tony J C Wang; Sandra Fontenla; Patrick McCann; Robert J Young; Stephen McNamara; Shyam Rao; James G Mechalakos; Nancy Y Lee Journal: J Radiat Oncol Date: 2013-02-28
Authors: Kilian Schiller; Hanno Martin Specht; Bernhard Haller; Daniela Hallqvist; Michal Devecka; Aaron Becker von Rose; Stephanie Elisabeth Combs; Steffi Pigorsch Journal: Radiat Oncol Date: 2017-07-04 Impact factor: 3.481