Literature DB >> 18237021

Synthesis, antifungal and antioxidant screening of some novel benzimidazole derivatives.

Ilgar Kerimov1, Gülgün Ayhan-Kilcigil, Benay Can-Eke, Nurten Altanlar, Mümtaz Iscan.   

Abstract

Some novel benzimidazole derivatives were synthesized and their in vitro effects on rat liver microsomal NADPH-dependent lipid peroxidation (LP) level, ethoxyresorufin O-deethylase (EROD) and antifungal activities were determined. A significant decrease in male rat liver microsomal LP level was noted by compounds 4c (52%), 4e (58%) and 4h (43%) at 10(-3) M concentration. Compounds 4c (100.0%), 4h (100.0%), 5c (98.0%) and 5h (100.0%) inhibited the microsomal ethoxyresorufin O-deethylase (EROD) enzyme activity better than that of the specific inhibitor caffeine (85%). Among these compounds, only compounds 4b and 4h exhibited moderate activity against C. albicans whereas the others had weak effects.

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Year:  2007        PMID： 18237021     DOI： 10.1080/14756360701228558

Source DB:  PubMed          Journal:  J Enzyme Inhib Med Chem        ISSN： 1475-6366            Impact factor:   5.051


  5 in total

1.  Evaluation of the Antioxidant Activity of Some Imines Containing 1H-Benzimidazoles.

Authors:  Rahman Başaran; Gülgün Kılcıgil; Benay Eke
Journal:  Turk J Pharm Sci       Date:  2020-12-23

2.  Pyrimido[1,2-a]benzimidazoles: synthesis and perspective of their pharmacological use.

Authors:  Victor V Fedotov; Vladimir L Rusinov; Evgeny N Ulomsky; Evgeny M Mukhin; Evgeny B Gorbunov; Oleg N Chupakhin
Journal:  Chem Heterocycl Compd (N Y)       Date:  2021-05-15       Impact factor: 1.490

3.  New Pyrazolo-Benzimidazole Mannich Bases with Antimicrobial and Antibiofilm Activities.

Authors:  Christina Zalaru; Florea Dumitrascu; Constantin Draghici; Isabela Tarcomnicu; Maria Marinescu; George Mihai Nitulescu; Rodica Tatia; Lucia Moldovan; Marcela Popa; Mariana Carmen Chifiriuc
Journal:  Antibiotics (Basel)       Date:  2022-08-12

4.  New (3-(1H-benzo[d]imidazol-2-yl))/(3-(3H-imidazo[4,5-b]pyridin-2-yl))-(1H-indol-5-yl)(3,4,5-trimethoxyphenyl)methanone conjugates as tubulin polymerization inhibitors.

Authors:  Kishore Mullagiri; V Lakshma Nayak; Satish Sunkari; Geeta Sai Mani; Sravanthi Devi Guggilapu; Burri Nagaraju; Abdullah Alarifi; Ahmed Kamal
Journal:  Medchemcomm       Date:  2017-12-12       Impact factor: 3.597

Review 5.  Antimicrobial potential of 1H-benzo[d]imidazole scaffold: a review.

Authors:  Sumit Tahlan; Sanjiv Kumar; Balasubramanian Narasimhan
Journal:  BMC Chem       Date:  2019-02-04
  5 in total

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