OBJECTIVES: To perform a longitudinal evaluation of high-sensitivity C-reactive protein (hs-CRP) in young people with type 1 diabetes in relation to the development of microalbuminuria (MA). RESEARCH DESIGN AND METHODS: hs-CRP was measured in 329 blood samples collected from 49 subjects with type 1 diabetes with MA and 49 normoalbuminuric subjects matched for age, sex, and duration of diabetes. RESULTS: In subjects developing MA, a progressive rise in hs-CRP was detected with levels significantly higher in the years after the onset of MA when compared with levels before MA onset (P = 0.003; age-adjusted P = 0.06). After the onset of MA, hs-CRP levels were significantly higher in subjects with MA when compared with normoalbuminuric subjects (median 1.9 mg/l [range 0.2-9.8] vs. 1.1 mg/l [0.2-6.4]; P = 0.02; adjusted P = 0.036). CONCLUSIONS: In this population of young subjects with type 1 diabetes, there was a significant increase in hs-CRP levels after the onset of MA, likely reflecting a general state of inflammation.
OBJECTIVES: To perform a longitudinal evaluation of high-sensitivity C-reactive protein (hs-CRP) in young people with type 1 diabetes in relation to the development of microalbuminuria (MA). RESEARCH DESIGN AND METHODS: hs-CRP was measured in 329 blood samples collected from 49 subjects with type 1 diabetes with MA and 49 normoalbuminuric subjects matched for age, sex, and duration of diabetes. RESULTS: In subjects developing MA, a progressive rise in hs-CRP was detected with levels significantly higher in the years after the onset of MA when compared with levels before MA onset (P = 0.003; age-adjusted P = 0.06). After the onset of MA, hs-CRP levels were significantly higher in subjects with MA when compared with normoalbuminuric subjects (median 1.9 mg/l [range 0.2-9.8] vs. 1.1 mg/l [0.2-6.4]; P = 0.02; adjusted P = 0.036). CONCLUSIONS: In this population of young subjects with type 1 diabetes, there was a significant increase in hs-CRP levels after the onset of MA, likely reflecting a general state of inflammation.
Authors: Kristen J Nadeau; Judith G Regensteiner; Timothy A Bauer; Mark S Brown; Jennifer L Dorosz; Amber Hull; Phil Zeitler; Boris Draznin; Jane E B Reusch Journal: J Clin Endocrinol Metab Date: 2009-11-13 Impact factor: 5.958
Authors: Lauren Winter; Lydia A Wong; George Jerums; Jas-Mine Seah; Michele Clarke; Sih Min Tan; Melinda T Coughlan; Richard J MacIsaac; Elif I Ekinci Journal: Front Endocrinol (Lausanne) Date: 2018-05-22 Impact factor: 5.555
Authors: Safinaz El Habashy; Amira Abd El Monem Adly; Mohamed Salah Eldin Mohamed Abdel Kader; Sherine El-Tokhy Ali Journal: Arch Med Sci Atheroscler Dis Date: 2019-12-31