Xiu-Fen Yang1, Yu Deng2, Hong Gu2, Apiradee Lim3, Torkel Snellingen4, Xi-Pu Liu4, Ning-Li Wang2, Amitha Domalpally5, Ronald Danis5, Ning-Pu Liu2. 1. Department of Ophthalmology, the Friendship Hospital, Capital Medical University, Beijing 100050, China; Beijing Tongren Eye Center, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China. 2. Beijing Tongren Eye Center, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China. 3. Department of Mathematics and Computer Science, Faculty of Science and Technology, Prince of Songkla University, Pattani Campus, Muang Pattani 9400, Thailand. 4. Sekwa Research Institute, Beijing 100088, China. 5. Fundus Photograph Reading Center, Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison 53705, Wisconsin, USA.
Abstract
AIM: To investigate the relationship between C-reactive protein (CRP) and diabetic retinopathy (DR) in a cohort of Chinese patients with type 2 diabetes mellitus (T2DM). METHODS: Community-based observational cohort study. There were 1131 participants recruited from November 2009 to September 2011 in Desheng community in urban Beijing. Patients diagnosed T2DM were recruited and underwent a standardized evaluation consisting of a questionnaire, ocular and anthropometric examinations and laboratory investigation. The presence and severity of DR were assessed by seven fields 30° color fundus photographs. Subjects were then classified into groups with no DR, any DR, or vision-threatening DR. CRP was analyzed from serum of study subjects. RESULTS: A total of 1007 patients with T2DM were included for analysis, including 408 (40.5%) men and 599 (59.5%) women. The median CRP level was 1.5 mg/L for women and 1.1 mg/L for men (P=0.004, OR 0.37, 95% CI 0.18-0.74). After adjusting for possible covariates, higher levels of CRP were associated with lower prevalence of any DR (P=0.02, OR 0.55, 95% CI 0.35-0.89), but not associated with vision-threatening DR (P=0.62, OR 0.78, 95% CI 0.28-2.14). After stratification by sex, the inverse association between CRP and DR was found to be statistically significant in men (P=0.006, OR 0.35, 95% CI 0.16-0.73), but not in women (P=0.58, OR 0.88, 95% CI 0.29-1.16). CONCLUSION: The data drawn from a Chinese population with T2DM suggest that increasing CRP levels may be inversely associated with development of DR.
AIM: To investigate the relationship between C-reactive protein (CRP) and diabetic retinopathy (DR) in a cohort of Chinese patients with type 2 diabetes mellitus (T2DM). METHODS: Community-based observational cohort study. There were 1131 participants recruited from November 2009 to September 2011 in Desheng community in urban Beijing. Patients diagnosed T2DM were recruited and underwent a standardized evaluation consisting of a questionnaire, ocular and anthropometric examinations and laboratory investigation. The presence and severity of DR were assessed by seven fields 30° color fundus photographs. Subjects were then classified into groups with no DR, any DR, or vision-threatening DR. CRP was analyzed from serum of study subjects. RESULTS: A total of 1007 patients with T2DM were included for analysis, including 408 (40.5%) men and 599 (59.5%) women. The median CRP level was 1.5 mg/L for women and 1.1 mg/L for men (P=0.004, OR 0.37, 95% CI 0.18-0.74). After adjusting for possible covariates, higher levels of CRP were associated with lower prevalence of any DR (P=0.02, OR 0.55, 95% CI 0.35-0.89), but not associated with vision-threatening DR (P=0.62, OR 0.78, 95% CI 0.28-2.14). After stratification by sex, the inverse association between CRP and DR was found to be statistically significant in men (P=0.006, OR 0.35, 95% CI 0.16-0.73), but not in women (P=0.58, OR 0.88, 95% CI 0.29-1.16). CONCLUSION: The data drawn from a Chinese population with T2DM suggest that increasing CRP levels may be inversely associated with development of DR.
Entities:
Keywords:
C-reactive protein; diabetic retinopathy; inflammation; type 2 diabetes mellitus
Authors: Helen K Li; Larry D Hubbard; Ronald P Danis; Adol Esquivel; Jose F Florez-Arango; Nicola J Ferrier; Elizabeth A Krupinski Journal: Invest Ophthalmol Vis Sci Date: 2010-05-19 Impact factor: 4.799
Authors: Laurence Shen Lim; E Shyong Tai; Paul Mitchell; Jie Jin Wang; Wan Ting Tay; Ecosse Lamoureux; Tien Yin Wong Journal: Invest Ophthalmol Vis Sci Date: 2010-09 Impact factor: 4.799
Authors: M V van Hecke; J M Dekker; G Nijpels; A C Moll; R J Heine; L M Bouter; B C P Polak; C D A Stehouwer Journal: Diabetologia Date: 2005-05-26 Impact factor: 10.122
Authors: A M W Spijkerman; M-A Gall; L Tarnow; J W R Twisk; E Lauritzen; H Lund-Andersen; J Emeis; H-H Parving; C D A Stehouwer Journal: Diabet Med Date: 2007-06-25 Impact factor: 4.359
Authors: Eric J Brunner; Mika Kivimäki; Daniel R Witte; Debbie A Lawlor; George Davey Smith; Jackie A Cooper; Michelle Miller; Gordon D O Lowe; Ann Rumley; Juan P Casas; Tina Shah; Steve E Humphries; Aroon D Hingorani; Michael G Marmot; Nicholas J Timpson; Meena Kumari Journal: PLoS Med Date: 2008-08-12 Impact factor: 11.069
Authors: Mayara Karla Dos Santos Nunes; Alexandre Sérgio Silva; Isabella Wanderley de Queiroga Evangelista; João Modesto Filho; Cecília Neta Alves Pegado Gomes; Rayner Anderson Ferreira do Nascimento; Rafaella Cristhine Pordeus Luna; Maria José de Carvalho Costa; Naila Francis Paulo de Oliveira; Darlene Camati Persuhn Journal: Diabetol Metab Syndr Date: 2017-10-18 Impact factor: 3.320