| Literature DB >> 18231758 |
Xu'e Chen1, Zhixiang Liu, Qing Yue.
Abstract
In order to investigate the role of TNF-and ICAM-1 in the pathogenesis of lichen planus, immunohistochemistry was used to detect the expression of TNF-and ICAM-1 in skin lesions of the patients with lichen planus and skin tissues of normal subjects. The results showed that positive rates of TNF-alpha and ICAM-1 expressions in lichen planus were significantly higher than those in normal skins (both P<0.05). Meanwhile, there was a obvious correlation between the increase of TNF-alpha and that of ICAM-1 in lichen planus. The expression of TNF-alpha and ICAM-1 might play an important role in the development of lichen planus.Entities:
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Year: 2007 PMID: 18231758 DOI: 10.1007/s11596-007-0632-x
Source DB: PubMed Journal: J Huazhong Univ Sci Technolog Med Sci ISSN: 1672-0733