Literature DB >> 18229938

Synthetic efforts toward the macrolactone core of Leucascandrolide A.

Laurent Ferrié1, Lucie Boulard, Fabienne Pradaux, Samir Bouzbouz, Sébastien Reymond, Patrice Capdevielle, Janine Cossy.   

Abstract

A chemoselective synthesis of 1, the macrocyclic core of leucascandrolide A, has been achieved by utilizing highly enantioselective allylmetalations, an enantioselective Noyori reduction of a propargylic ketone, and olefin metatheses as the key steps.

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Year:  2008        PMID: 18229938     DOI: 10.1021/jo701315h

Source DB:  PubMed          Journal:  J Org Chem        ISSN: 0022-3263            Impact factor:   4.354


  5 in total

1.  Structural determination of NSC 670224, synthesis of analogues and biological evaluation.

Authors:  Nathaniel B Zuckerman; Andrew S Myers; Tiffani K Quan; Walter M Bray; R Scott Lokey; Grant A Hartzog; Joseph P Konopelski
Journal:  ChemMedChem       Date:  2012-02-29       Impact factor: 3.466

2.  Total synthesis of neopeltolide and analogs.

Authors:  Yubo Cui; Wangyang Tu; Paul E Floreancig
Journal:  Tetrahedron       Date:  2010-06-26       Impact factor: 2.457

3.  1,n-glycols as dialdehyde equivalents in iridium-catalyzed enantioselective carbonyl allylation and iterative two-directional assembly of 1,3-polyols.

Authors:  Yu Lu; In Su Kim; Abbas Hassan; David J Del Valle; Michael J Krische
Journal:  Angew Chem Int Ed Engl       Date:  2009       Impact factor: 15.336

4.  Approach to the Synthesis of the C1-C11 and C14-C18 portion of Leucascandrolide A.

Authors:  T J Hunter; J Zheng; G A O'Doherty
Journal:  Org Chem Front       Date:  2016-07-12       Impact factor: 5.281

5.  Enantiocontrolled Preparation of ϒ-Substituted Cyclohexenones: Synthesis and Kinase Activity Assays of Cyclopropyl-Fused Cyclohexane Nucleosides.

Authors:  Sergio Jurado; Beatriz Domínguez-Pérez; Ona Illa; Jan Balzarini; Félix Busqué; Ramon Alibés
Journal:  Int J Mol Sci       Date:  2022-08-26       Impact factor: 6.208

  5 in total

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