Literature DB >> 22378491

Structural determination of NSC 670224, synthesis of analogues and biological evaluation.

Nathaniel B Zuckerman1, Andrew S Myers, Tiffani K Quan, Walter M Bray, R Scott Lokey, Grant A Hartzog, Joseph P Konopelski.   

Abstract

Follow my lead! NSC 670224, previously shown to be toxic to Saccharomyces cerevisiae at low micromolar concentrations, potentially acts via a mechanism of action related to that of tamoxifen (NSC 180973), breast cancer drug. The structure of NSC 670224, previously thought to be a 2,4-dichloro arene, was established as the 3,4-dichloro arene, and a focused library of analogues were synthesized and biologically evaluated.
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Year:  2012        PMID： 22378491      PMCID： PMC3516922          DOI： 10.1002/cmdc.201200038

Source DB:  PubMed          Journal:  ChemMedChem        ISSN： 1860-7179            Impact factor:   3.466


  17 in total

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Authors:  Guri Giaever; Patrick Flaherty; Jochen Kumm; Michael Proctor; Corey Nislow; Daniel F Jaramillo; Angela M Chu; Michael I Jordan; Adam P Arkin; Ronald W Davis
Journal:  Proc Natl Acad Sci U S A       Date:  2004-01-12       Impact factor: 11.205

2.  Exploring the mode-of-action of bioactive compounds by chemical-genetic profiling in yeast.

Authors:  Ainslie B Parsons; Andres Lopez; Inmar E Givoni; David E Williams; Christopher A Gray; Justin Porter; Gordon Chua; Richelle Sopko; Renee L Brost; Cheuk-Hei Ho; Jiyi Wang; Troy Ketela; Charles Brenner; Julie A Brill; G Esteban Fernandez; Todd C Lorenz; Gregory S Payne; Satoru Ishihara; Yoshikazu Ohya; Brenda Andrews; Timothy R Hughes; Brendan J Frey; Todd R Graham; Raymond J Andersen; Charles Boone
Journal:  Cell       Date:  2006-08-11       Impact factor: 41.582

3.  Origin of diastereoselectivity in the tandem oxy-Cope/Claisen/ene reaction: experimental and theoretical studies of the ring inversion mechanism.

Authors:  Effiette L O Sauer; James Hooper; Tom Woo; Louis Barriault
Journal:  J Am Chem Soc       Date:  2007-01-27       Impact factor: 15.419

4.  The chemical genomic portrait of yeast: uncovering a phenotype for all genes.

Authors:  Maureen E Hillenmeyer; Eula Fung; Jan Wildenhain; Sarah E Pierce; Shawn Hoon; William Lee; Michael Proctor; Robert P St Onge; Mike Tyers; Daphne Koller; Russ B Altman; Ronald W Davis; Corey Nislow; Guri Giaever
Journal:  Science       Date:  2008-04-18       Impact factor: 47.728

5.  Anti-sulfonylbenzoate antibodies as a tool for the detection of nucleotide-binding proteins for functional proteomics.

Authors:  Lisa L Moore; Ashley M Fulton; Marietta L Harrison; Robert L Geahlen
Journal:  J Proteome Res       Date:  2004 Nov-Dec       Impact factor: 4.466

6.  Accelerating the discovery of biologically active small molecules using a high-throughput yeast halo assay.

Authors:  Nadine C Gassner; Craig M Tamble; Jonathan E Bock; Naomi Cotton; Kimberly N White; Karen Tenney; Robert P St Onge; Michael J Proctor; Guri Giaever; Corey Nislow; Ronald W Davis; Phillip Crews; Theodore R Holman; R Scott Lokey
Journal:  J Nat Prod       Date:  2007-02-10       Impact factor: 4.050

7.  The genetic landscape of a cell.

Authors:  Michael Costanzo; Anastasia Baryshnikova; Jeremy Bellay; Yungil Kim; Eric D Spear; Carolyn S Sevier; Huiming Ding; Judice L Y Koh; Kiana Toufighi; Sara Mostafavi; Jeany Prinz; Robert P St Onge; Benjamin VanderSluis; Taras Makhnevych; Franco J Vizeacoumar; Solmaz Alizadeh; Sondra Bahr; Renee L Brost; Yiqun Chen; Murat Cokol; Raamesh Deshpande; Zhijian Li; Zhen-Yuan Lin; Wendy Liang; Michaela Marback; Jadine Paw; Bryan-Joseph San Luis; Ermira Shuteriqi; Amy Hin Yan Tong; Nydia van Dyk; Iain M Wallace; Joseph A Whitney; Matthew T Weirauch; Guoqing Zhong; Hongwei Zhu; Walid A Houry; Michael Brudno; Sasan Ragibizadeh; Balázs Papp; Csaba Pál; Frederick P Roth; Guri Giaever; Corey Nislow; Olga G Troyanskaya; Howard Bussey; Gary D Bader; Anne-Claude Gingras; Quaid D Morris; Philip M Kim; Chris A Kaiser; Chad L Myers; Brenda J Andrews; Charles Boone
Journal:  Science       Date:  2010-01-22       Impact factor: 47.728

8.  Synthetic studies on gambieric acids, potent antifungal polycyclic ether natural products: reassignment of the absolute configuration of the nonacyclic polyether core by NMR analysis of model compounds.

Authors:  Haruhiko Fuwa; Kazuya Ishigai; Tomomi Goto; Akihiro Suzuki; Makoto Sasaki
Journal:  J Org Chem       Date:  2009-06-05       Impact factor: 4.354

9.  Antifungal activity of tamoxifen: in vitro and in vivo activities and mechanistic characterization.

Authors:  Kristy Dolan; Sara Montgomery; Bradley Buchheit; Louis Didone; Melanie Wellington; Damian J Krysan
Journal:  Antimicrob Agents Chemother       Date:  2009-06-01       Impact factor: 5.191

10.  Hypoxia-selective 3-alkyl 1,2,4-benzotriazine 1,4-dioxides: the influence of hydrogen bond donors on extravascular transport and antitumor activity.

Authors:  Michael P Hay; Karin Pchalek; Frederik B Pruijn; Kevin O Hicks; Bronwyn G Siim; Robert F Anderson; Sujata S Shinde; Victoria Phillips; William A Denny; William R Wilson
Journal:  J Med Chem       Date:  2007-12-06       Impact factor: 7.446
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  1 in total

1.  Construction of congested Csp3-Csp3 bonds by a formal Ni-catalyzed alkylboration.

Authors:  Amit Kumar Simlandy; Stephen R Sardini; M Kevin Brown
Journal:  Chem Sci       Date:  2021-03-09       Impact factor: 9.825
  1 in total

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