BACKGROUND: The aim of our study was to evaluate the accuracy of magnetic resonance imaging (MRI) in evaluating Crohn's disease (CD) activity compared to clinical/laboratory data. METHODS: Ninety-three consecutive patients with CD were prospectively studied by MR imaging, before and after Gadolinium chelates administration, with use of a biphasic endoluminal contrast agent. MR image analysis included: number of lesions, presence/absence of bowel stenosis, upstream bowel dilation, wall thickness, presence of enhancement, enhancement pattern, presence/absence of comb sign, lymph nodes, and perianal fistulas/abscesses. Clinical evaluation was performed by means of Harvey & Bradshaw Index. Acute-phase reactants were considered standard of reference to monitor biological activity (BA). MR imaging findings were compared with clinical and laboratory data. RESULTS: MR image analysis detected: In 96 exams multiple lesions in 16, 1 in 50; no lesions in 30; stenosis in 52; dilatation in 28; wall thickening in 59; significant enhancement in 57; layered pattern in 50; comb sign in 37; enlarged lymph nodes in 16; fibro-fatty proliferation in 40; fistulas in 9. CONCLUSIONS: MRI is able to depict morphological changes and is helpful in assessing Crohn's inflammatory disease.
BACKGROUND: The aim of our study was to evaluate the accuracy of magnetic resonance imaging (MRI) in evaluating Crohn's disease (CD) activity compared to clinical/laboratory data. METHODS: Ninety-three consecutive patients with CD were prospectively studied by MR imaging, before and after Gadolinium chelates administration, with use of a biphasic endoluminal contrast agent. MR image analysis included: number of lesions, presence/absence of bowel stenosis, upstream bowel dilation, wall thickness, presence of enhancement, enhancement pattern, presence/absence of comb sign, lymph nodes, and perianal fistulas/abscesses. Clinical evaluation was performed by means of Harvey & Bradshaw Index. Acute-phase reactants were considered standard of reference to monitor biological activity (BA). MR imaging findings were compared with clinical and laboratory data. RESULTS: MR image analysis detected: In 96 exams multiple lesions in 16, 1 in 50; no lesions in 30; stenosis in 52; dilatation in 28; wall thickening in 59; significant enhancement in 57; layered pattern in 50; comb sign in 37; enlarged lymph nodes in 16; fibro-fatty proliferation in 40; fistulas in 9. CONCLUSIONS: MRI is able to depict morphological changes and is helpful in assessing Crohn's inflammatory disease.
Authors: S Cappabianca; V Granata; G Di Grezia; Y Mandato; A Reginelli; V Di Mizio; R Grassi; A Rotondo Journal: Radiol Med Date: 2010-10-27 Impact factor: 3.469
Authors: E Garofalo; A Spinelli; G Pellino; K Flashman; M Frasson; M Carvello; N de'Angelis; A Garcia-Granero; M Harper; J Warusavitarne; M Coleman; E Espin; F Selvaggi Journal: Surg Endosc Date: 2020-04-02 Impact factor: 4.584