Literature DB >> 18227178

Killing of Neisseria gonorrhoeae, Streptococcus agalactiae (group B streptococcus), Haemophilus ducreyi, and vaginal Lactobacillus by 3-O-octyl-sn-glycerol.

B J Moncla1, K Pryke, Charles E Isaacs.   

Abstract

The microbicide candidate octylglycerol inactivates sexually transmitted bacterial pathogens at concentrations which spare normal vaginal flora (lactobacillus). Standard minimum microbicidal concentration assays and time-kill assays revealed the drug concentrations and times required for inactivation. Octylglycerol concentrations must exceed the binding capacity of any human serum albumin to be effective.

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Year:  2008        PMID： 18227178      PMCID： PMC2292550          DOI： 10.1128/AAC.01023-07

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  6 in total

1.  Why nonoxynol-9 may have failed to prevent acquisition of Neisseria gonorrhoeae in clinical trials.

Authors:  Bernard J Moncla; Sharon L Hillier
Journal:  Sex Transm Dis       Date:  2005-08       Impact factor: 2.830

2.  Use of frozen-thawed cervical tissues in the organ culture system to measure anti-HIV activities of candidate microbicides.

Authors:  Phalguni Gupta; Deena Ratner; Bruce K Patterson; Kathy Kulka; Lisa C Rohan; Michael A Parniak; Charles E Isaacs; Sharon Hillier
Journal:  AIDS Res Hum Retroviruses       Date:  2006-05       Impact factor: 2.205

3.  Killing kinetics of caspofungin, micafungin, and amphotericin B against Candida guilliermondii.

Authors:  Emilia Cantón; Javier Pemán; Macrina Sastre; Mónica Romero; Ana Espinel-Ingroff
Journal:  Antimicrob Agents Chemother       Date:  2006-08       Impact factor: 5.191

4.  Killing of Chlamydia trachomatis by novel antimicrobial lipids adapted from compounds in human breast milk.

Authors:  M F Lampe; L M Ballweber; C E Isaacs; D L Patton; W E Stamm
Journal:  Antimicrob Agents Chemother       Date:  1998-05       Impact factor: 5.191

5.  A lipid-peptide microbicide inactivates herpes simplex virus.

Authors:  Charles E Isaacs; Jun Hua Jia; Weimin Xu
Journal:  Antimicrob Agents Chemother       Date:  2004-08       Impact factor: 5.191

6.  Determination of decimal reduction time (D value) of chemical agents used in hospitals for disinfection purposes.

Authors:  Priscila Gava Mazzola; Thereza Christina Vessoni Penna; Alzira M da S Martins
Journal:  BMC Infect Dis       Date:  2003-10-17       Impact factor: 3.090
  6 in total
  10 in total

1.  Development of a liposome microbicide formulation for vaginal delivery of octylglycerol for HIV prevention.

Authors:  Lin Wang; Alexandra Beumer Sassi; Dorothy Patton; Charles Isaacs; B J Moncla; Phalguni Gupta; Lisa Cencia Rohan
Journal:  Drug Dev Ind Pharm       Date:  2011-12-10       Impact factor: 3.225

Review 2.  Vaginal drug delivery systems for HIV prevention.

Authors:  Lisa Cencia Rohan; Alexandra B Sassi
Journal:  AAPS J       Date:  2009-02-05       Impact factor: 4.009

3.  Development and Characterization of a Vaginal Film Containing Dapivirine, a Non- nucleoside Reverse Transcriptase Inhibitor (NNRTI), for prevention of HIV-1 sexual transmission.

Authors:  Ayman Akil; Michael A Parniak; Charlene S Dezzuitti; Bernard J Moncla; Marilyn R Cost; Mingguang Li; Lisa Cencia Rohan
Journal:  Drug Deliv Transl Res       Date:  2011-06-01       Impact factor: 4.617

4.  Testing of viscous anti-HIV microbicides using Lactobacillus.

Authors:  B J Moncla; K Pryke; L C Rohan; H Yang
Journal:  J Microbiol Methods       Date:  2011-12-24       Impact factor: 2.363

5.  Evaluation of WLBU2 peptide and 3-O-octyl-sn-glycerol lipid as active ingredients for a topical microbicide formulation targeting Chlamydia trachomatis.

Authors:  M C Skinner; A O Kiselev; C E Isaacs; T A Mietzner; R C Montelaro; M F Lampe
Journal:  Antimicrob Agents Chemother       Date:  2009-12-14       Impact factor: 5.191

6.  Chlamydia trachomatis laboratory strains versus recent clinical isolates: implications for routine microbicide testing.

Authors:  M C Skinner; W E Stamm; M L Lampe
Journal:  Antimicrob Agents Chemother       Date:  2009-02-02       Impact factor: 5.191

7.  In vitro and ex vivo testing of tenofovir shows it is effective as an HIV-1 microbicide.

Authors:  Lisa C Rohan; Bernard J Moncla; Ratiya Pamela Kunjara Na Ayudhya; Marilyn Cost; Yunda Huang; Fang Gai; Nicole Billitto; J D Lynam; Kara Pryke; Phillip Graebing; Nicole Hopkins; James F Rooney; David Friend; Charlene S Dezzutti
Journal:  PLoS One       Date:  2010-02-19       Impact factor: 3.240

8.  Formulation and characterization of polymeric films containing combinations of antiretrovirals (ARVs) for HIV prevention.

Authors:  Ayman Akil; Hrushikesh Agashe; Charlene S Dezzutti; Bernard J Moncla; Sharon L Hillier; Brid Devlin; Yuan Shi; Kevin Uranker; Lisa Cencia Rohan
Journal:  Pharm Res       Date:  2014-07-31       Impact factor: 4.200

9.  Is wetter better? An evaluation of over-the-counter personal lubricants for safety and anti-HIV-1 activity.

Authors:  Charlene S Dezzutti; Elizabeth R Brown; Bernard Moncla; Julie Russo; Marilyn Cost; Lin Wang; Kevin Uranker; Ratiya P Kunjara Na Ayudhya; Kara Pryke; Jim Pickett; Marc-André Leblanc; Lisa C Rohan
Journal:  PLoS One       Date:  2012-11-07       Impact factor: 3.240

Review 10.  Group B Streptococcal Maternal Colonization and Neonatal Disease: Molecular Mechanisms and Preventative Approaches.

Authors:  Kathryn A Patras; Victor Nizet
Journal:  Front Pediatr       Date:  2018-02-22       Impact factor: 3.418
  10 in total

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