| Literature DB >> 18226900 |
Alan D Brown1, Mark E Bunnage, Paul A Glossop, Kim James, Rhys Jones, Charlotte A L Lane, Russell A Lewthwaite, Simon Mantell, Christelle Perros-Huguet, David A Price, Mike Trevethick, Rob Webster.
Abstract
The design and profile of a series of adamantyl-containing long acting beta(2)-adrenoreceptor agonists are described. An optimal pharmacokinetic profile of low oral bioavailability was combined with a strong pharmacology profile when assessed using a guinea pig trachea tissue model. A focus was then placed on developing a robust synthetic route to ensure rapid delivery of material for clinical trials.Entities:
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Year: 2008 PMID： 18226900 DOI： 10.1016/j.bmcl.2008.01.034
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823