C Lawrence Kien1, Janice Y Bunn. 1. Department of Pediatrics, University of Vermont, Burlington, Vermont, USA. cl.kien@uvm.edu
Abstract
OBJECTIVE: Because estrogen and testosterone affect transcription factors regulating mitochondrial function, we assessed the effects of gender on the metabolic response to dietary palmitic acid (PA) vs. oleic acid (OA) in subjects participating in a previously described trial. METHODS AND PROCEDURES: Adults (N = 43) were studied after following a baseline diet (PA = 8.4% kcal, OA = 13.1% kcal) and after undergoing one of two experimental diets: high PA (HI PA) (PA = 16.8%, OA = 16.4% kcal) (N = 21; 11 men) or high OA (HI OA) (PA = 1.7%, and OA = 31.4%) (N = 22; 11 men). RESULTS: Relative to baseline, the rate of fatty acid (FA) oxidation (% resting energy expenditure(REE)) (mean +/- s.e.m.) increased in women on HI OA while decreasing on HI PA in the fed (+11.8 +/- 5.6% vs. -6.3 +/- 4.2%, P = 0.02) and fasting states (+13.4 +/- 4.2% vs. -12.7 +/- 6.9%, P = 0.047), but changes in men were not statistically significant. Daily energy expenditure changed only in men, increasing on HI OA and decreasing on HI PA (+66 +/- 61 kcal/day or 1.2 +/- 1.0 kcal/kg fat-free mass (FFM)/day vs. -266 +/- 78 kcal/day or -4.2 +/- 1.3 kcal/kg FFM/day, P = 0.004 and P = 0.007, respectively). DISCUSSION: Increased dietary PA/OA caused decreased FA oxidation in women, in the fed and fasted states and decreased daily energy expenditure (DEE) in men.
RCT Entities:
OBJECTIVE: Because estrogen and testosterone affect transcription factors regulating mitochondrial function, we assessed the effects of gender on the metabolic response to dietary palmitic acid (PA) vs. oleic acid (OA) in subjects participating in a previously described trial. METHODS AND PROCEDURES: Adults (N = 43) were studied after following a baseline diet (PA = 8.4% kcal, OA = 13.1% kcal) and after undergoing one of two experimental diets: high PA (HI PA) (PA = 16.8%, OA = 16.4% kcal) (N = 21; 11 men) or high OA (HI OA) (PA = 1.7%, and OA = 31.4%) (N = 22; 11 men). RESULTS: Relative to baseline, the rate of fatty acid (FA) oxidation (% resting energy expenditure(REE)) (mean +/- s.e.m.) increased in women on HI OA while decreasing on HI PA in the fed (+11.8 +/- 5.6% vs. -6.3 +/- 4.2%, P = 0.02) and fasting states (+13.4 +/- 4.2% vs. -12.7 +/- 6.9%, P = 0.047), but changes in men were not statistically significant. Daily energy expenditure changed only in men, increasing on HI OA and decreasing on HI PA (+66 +/- 61 kcal/day or 1.2 +/- 1.0 kcal/kg fat-free mass (FFM)/day vs. -266 +/- 78 kcal/day or -4.2 +/- 1.3 kcal/kg FFM/day, P = 0.004 and P = 0.007, respectively). DISCUSSION: Increased dietary PA/OA caused decreased FA oxidation in women, in the fed and fasted states and decreased daily energy expenditure (DEE) in men.
Authors: John P Thyfault; Melanie G Cree; Donghai Zheng; Jennifer J Zwetsloot; Edward B Tapscott; Timothy R Koves; Olga Ilkayeva; Robert R Wolfe; Deborah M Muoio; G Lynis Dohm Journal: Am J Physiol Cell Physiol Date: 2006-10-18 Impact factor: 4.249
Authors: Jiandie Lin; Hai Wu; Paul T Tarr; Chen-Yu Zhang; Zhidan Wu; Olivier Boss; Laura F Michael; Pere Puigserver; Eiji Isotani; Eric N Olson; Bradford B Lowell; Rhonda Bassel-Duby; Bruce M Spiegelman Journal: Nature Date: 2002-08-15 Impact factor: 49.962
Authors: Yong-Xu Wang; Chun-Li Zhang; Ruth T Yu; Helen K Cho; Michael C Nelson; Corinne R Bayuga-Ocampo; Jungyeob Ham; Heonjoong Kang; Ronald M Evans Journal: PLoS Biol Date: 2004-08-24 Impact factor: 8.029
Authors: C Lawrence Kien; Karen I Everingham; Robert D Stevens; Naomi K Fukagawa; Deborah M Muoio Journal: Obesity (Silver Spring) Date: 2010-06-17 Impact factor: 5.002
Authors: C Lawrence Kien; Janice Y Bunn; Naomi K Fukagawa; Vikas Anathy; Dwight E Matthews; Karen I Crain; David B Ebenstein; Emily K Tarleton; Richard E Pratley; Matthew E Poynter Journal: J Nutr Biochem Date: 2015-08-01 Impact factor: 6.048
Authors: C Lawrence Kien; Janice Y Bunn; Robert Stevens; James Bain; Olga Ikayeva; Karen Crain; Timothy R Koves; Deborah M Muoio Journal: Am J Clin Nutr Date: 2014-01-15 Impact factor: 7.045