| Literature DB >> 27424223 |
Merla J Hubler1, Arion J Kennedy2.
Abstract
Immune cell plasticity has extensive implications in the pathogenesis and resolution of metabolic disorders, cancers, autoimmune diseases and chronic inflammatory disorders. Over the past decade, nutritional status has been discovered to influence the immune response. In metabolic disorders such as obesity, immune cells interact with various classes of lipids, which are capable of controlling the plasticity of macrophages and T lymphocytes. The purpose of this review is to discuss lipids and their impact on innate and adaptive immune responses, focusing on two areas: (1) the impact of altering lipid metabolism on immune cell activation, differentiation and function and (2) the mechanism by which lipids such as cholesterol and fatty acids regulate immune cell plasticity.Entities:
Keywords: Fatty acids; Inflammation; Macrophages; Oxysterols; T lymphocytes
Mesh：
Substances：
Year: 2015 PMID： 27424223 PMCID： PMC5694687 DOI： 10.1016/j.jnutbio.2015.11.002
Source DB: PubMed Journal: J Nutr Biochem ISSN： 0955-2863 Impact factor: 6.048