Methods in determination of selenium states.

Selenium status in man has been assessed either by determination of the selenium concentration in biological materials or by the measurement of biochemical or clinical selenium-dependent functions. Over and above the discussion of normal levels and of the numerous factors liable to influence the above mentioned indices, the present review more specifically deals with the sensitivity of various parameters to changing selenium status, both in deficiency states and in over-exposure to the element, and the attempt is made to establish the specificity of these indicators in the diagnosis of selenium states. The possibilities for defining "adequate" or "optimum" selenium concentrations are also examined.